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Pulmonary infection and inflammation

Author: Mieczyslaw Pokorski
Publisher: Switzerland : Springer, 2016.
Series: Advances in experimental medicine and biology, v. 935.; Advances in experimental medicine and biology., Neuroscience and respiration ;, v. 26.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Pulmonary diseases are the major cause of human morbidity, taxing the health care system due to disease prevalence, chronicity, and social and fiscal costs. This book concentrates on the inflammatory and immunogenic settings of pulmonary disorders and related medical areas. Excessive inflammation causes lung injury and forms a conducive background for pathogenic infections, particularly in immuno-compromised hosts.  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Erscheint auch als:
Pokorski, Mieczyslaw. Pulmonary Infection and Inflammation
Druck-Ausgabe
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Mieczyslaw Pokorski
ISBN: 9783319444857 3319444859
OCLC Number: 956505389
Notes: Includes index.
Description: 1 online resource (viii, 100 pages).
Contents: Preface; Contents; Prevalence of Pulmonary Infections Caused by Atypical Pathogens in non-HIV Immunocompromised Patients; 1 Introduction; 2 Methods; 2.1 Patients; 2.2 Bronchoscopy Procedure; 2.3 Microbiological Procedure; 2.4 Data Collection and Analysis; 3 Results; 4 Discussion; References; Effects of S-Nitroso-N-Acetyl-Penicillamine (SNAP) on Inflammation, Lung Tissue Apoptosis and iNOS Activity in a Rabbit Model ...; 1 Introduction; 2 Methods; 2.1 General Design of Experiments; 2.2 Counting of Cells in Bronchoalveolar Fluid (BALF); 2.3 Expression of iNOS mRNA Using Quantitative PCR 2.4 Markers of Inflammation and Lung Injury2.4.1 Preparation of Lung Tissue Homogenate; 2.4.2 Measurement of Markers of Inflammation and Lung Injury by Enzyme-Linked Immunosorbent Assay (ELISA); 2.4.3 Measurement of Lipid Peroxidation; 2.4.4 Measurement of Nitrite/Nitrate Concentration; 2.5 Apoptosis Assays; 2.5.1 In Situ Labeling of DNA Strand Breaks by TUNEL Method; 2.5.2 Measurement of Caspase-3 Concentration in the Lung Homogenate by ELISA Method; 2.6 Statistical Analysis; 3 Results; 3.1 Cells in BALF; 3.2 Markers of Inflammation and Lung Injury 3.3 iNOS mRNA in Lung Tissue and Nitrite/Nitrate in Plasma3.4 Apoptosis in Lung Tissue; 4 Discussion; 5 Conclusions; References; Combination Therapy with Budesonide and Salmeterol in Experimental Allergic Inflammation; 1 Introduction; 2 Methods; 2.1 Experimental Groups; 2.2 Experimentally Induced Allergic Airway Inflammation; 2.3 Evaluation of Airway Smooth Muscle Reactivity in Vivo; 2.4 Evaluation of Cough Reflex in Vivo; 2.5 Evaluation of Ciliary Beat Frequency (CBF) in Vitro; 2.6 Evaluation of Cytokines in Bronchoalveolar Lavage Fluid (BALF); 2.7 Statistical Analysis; 3 Results 3.1 Cough Reflex3.2 Airway Reactivity --
Specific Airway Resistance (sRaw); 3.3 Ciliary Beat Frequency (CBF); 3.4 Inflammatory Cytokines in Bronchoalveolar Fluid (BALF); 4 Discussion; References; Monoclonal Antibodies for the Management of Severe Asthma; 1 Introduction; 2 Omalizumab; 2.1 Clinical Efficacy; 3 Other Anti-IgE Antibodies; 3.1 Mepolizumab; 3.2 Reslizumab; 3.3 Benralizumab; 3.4 Anrukinzumab/Lebrikizumab/Tralokinumab; 3.5 Daclizumab; 3.6 Dupilumab; 3.7 T helper (Th) cytokines; 3.8 Brodalumab; 4 Other Candidate Anti-Inflammatory Drugs with Potential Therapeutic Effect in Asthma
Series Title: Advances in experimental medicine and biology, v. 935.; Advances in experimental medicine and biology., Neuroscience and respiration ;, v. 26.
Responsibility: Mieczyslaw Pokorski, editor.

Abstract:

Pulmonary diseases are the major cause of human morbidity, taxing the health care system due to disease prevalence, chronicity, and social and fiscal costs. Inflammation also is an essential  Read more...

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