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Razoxane and dexrazoxane - two multifunctional agents : experimental and clinical results

Author: Walter Rhomberg; K Hellmann
Publisher: Dordrecht ; London : Springer, 2010.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
"Razoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radiotherapy especially in the treatment of soft tissue sarcomas and gastrointestinal neoplasms. They protect  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Razoxane and dexrazoxane - two multifunctional agents.
Dordrecht ; London : Springer, 2010
(OCoLC)642291124
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Walter Rhomberg; K Hellmann
ISBN: 9789048191680 9048191688
OCLC Number: 668097288
Description: 1 online resource (: v.: digital
Contents: PREFACE1. INTRODUCTION; Hellmann, K.1.1 Overview of the development of razoxane and dexrazoxane2. RAZOXANE 2.1 Preclinical data - in vitro and in vivo; Hellmann, K. 2.2 Modes of action, a brief summary; Rhomberg, W. 2.3 Clinical studies of malignant tumors; Rhomberg, W. 2.3.1 Razoxane as cytotoxic or cytostatic agent 2.3.1.1 Leukaemias and lymphomas 2.3.1.2 Solid tumors, single agent 2.3.1.3 Solid tumors, multiagent therapy 2.3.1.4 Adjuvant use of razoxane 2.3.2 Razoxane as radiosensitizer 2.3.2.1 Soft tissue- and osteosarcomas, chordomas 2.3.2.2 Gastro-intestinal malignancies 2.3.2.3 Lung cancer 2.3.2.4 Other solid tumors 2.3.3 Antimetastatic efficacy 2.3.3.1 Preclinical evidence; Rhomberg, W. 2.3.3.2 Metastasis and the entry of tumor cells into; the vasculature - prevention by razoxane; Hellmann, K. 2.3.3.3 Clinical evidence; Rhomberg, W. 2.3.4 Razoxane - a cytorallentaric drug; Hellmann, K. 2.3.5 Toxicity; Rhomberg, W. 2.4 Studies in non-malignant diseases 2.4.1 Psoriasis and psoriatric arthropathy; Rhomberg, W. 2.4.2 Crohn's disease and ulcerative colitis; Rhomberg, W. 3. DEXRAZOXANE 3.1 Preface 3.2 The pharmacology of dexrazoxane; Hasinoff, B.B. 3.3 Toxicology and pharmacokinetics; Hellmann, K. 3.4 Identification of dexrazoxane as a cardioprotector; Herman, E. 3.5 Clinical considerations 3.5.1 Dexrazoxane as antitumour agent; Rhomberg, W. 3.5.2 Protection against anthracyclin-induced cardiotoxicity: 3.5.2.1 Two pivotal clinical studies. A report including pharmacology and safety issues; Rubens, R. 3.5.2.2 Comments on study 88001 and 88006; Hellmann, K. 3.5.2.3 Clinical studies on cardioprotection - an update; Jones, R. 3.5.3 Non-cardioprotective efficacy; Langer, S.W. 3.5.4 Neurodegenerative diseases; Greig, N. 4. SUMMARY and OUTLOOK; Hellmann, K. and Rhomberg, W.
Responsibility: Walter Rhomberg, Kurt Hellmann, editors.

Abstract:

This book provides an overview on razoxane and dexrazoxane, novel drugs with uniquely useful features. There are indications that the proteins thought to be responsible for the ravages of Alzheimer's  Read more...

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