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|All Authors / Contributors:||
Artur Pinto; Jieping Zhu; Université de Paris-Sud. Faculté des Sciences d'Orsay (Essonne).
|Description:||1 vol. (432 p.) : ill. en coul. ; 30 cm.|
|Responsibility:||Artur Pinto ; sous la direction de [Zhu Jieping].|
The scientific project involved the development of new palladium catalyzed domino and multi-components reaction for heterocycles synthesis. First we have described a new synthesis of physostigmine which relies on a domino Heck / cyanation reaction key step. An asymmetric version of this reaction has also been developed. In a second part, we have developed a synthesis of 3-(diarylmethylene)oxindoles by a carbopalladation / CH activation / arylation domino process from easily accessible products. Then, with the success of this reaction, two multi-component reactions have been devised. The first one combines a Sonogashira reaction with the carbopalladation / CH fonctionalisation, the second one combines a alladium catalysed amidation reaction with the same domino reaction. During the development of the last domino sequence, we have uncovered a new way to synthesize 6-aryluracil: the synthesis involved a simple dimerisation reaction of 3-arylpropynamide. In the last part, we have carried out preliminary studies to develop a new dihydropyrrole multi-component synthesis using the reactivityof isonitrile and allyl.