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Recent Advances in Cell Biology of Acute Leukemia : Impact on Clinical Diagnosis and Therapy

Author: Wolf-Dieter Ludwig; Eckhard Thiel
Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 1993.
Series: Recent results in cancer research, 131.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
This volume gives an overview of the state of the art regarding cell-biological features of acute leukemias. Based on survey articles and results of clinical multicenter studies in children and adults with ALL or AML, it offers a detailed presentation concerning the significance of immunologic, cytogenetic and molecular-biologic analyses in the classification of acute leukemia and the identification of clinical risk  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Wolf-Dieter Ludwig; Eckhard Thiel
ISBN: 9783642848957 3642848958
OCLC Number: 851392521
Description: 1 online resource (xv, 407 pages 98 illustrations, 3 illustrations in color.).
Contents: Contents Hematopoietic Differentiation --
Phenotypic Heterogeneity in Acute Leukemias, Immunological Characterization and Clinical Relevance --
Biological and Clinical Significance of Cytogenetic Abnormalities in Acute Leukemias --
Minimal Residual Disease in Acute Leukemias, Detection and Immunotherapeutic Strategies --
Immunophenotypic and Molecular Genetic Characterization of Acute Lymphoblastic Leukemia --
Leukemic Cell Characterization in Acute Myeloid Leukemia.-
Series Title: Recent results in cancer research, 131.
Responsibility: edited by Wolf-Dieter Ludwig, Eckhard Thiel.

Abstract:

This volume gives an overview of the state of the art regarding cell-biological features of acute leukemias. Based on survey articles and results of clinical multicenter studies in children and adults with ALL or AML, it offers a detailed presentation concerning the significance of immunologic, cytogenetic and molecular-biologic analyses in the classification of acute leukemia and the identification of clinical risk groups. Current immunological and molecular-biological techniques for detecting minimal residual disease are described and their possibilities and limitations discussed. Further main topics include preclinical investigations and first clinical experience with interleukin 2-based immunotherapy in acute leukemia, biological features of new hematopoietic growth factors and recent advanced in the molecular understanding of the genetic defects in leukemic cells.

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