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Recent advances in the chemistry of ss-Lactam antibiotics

Author: P H Bentley; R Southgate
Publisher: Royal Society of Chemistry, 1989.
Series: Special publication (Royal Society of Chemistry), 70.
Edition/Format:   Print book : Conference publication : EnglishView all editions and formats

A collection of papers from a conference on B-lactam antibiotics in which the contributors discuss the progress of scientific understanding of the synthesis, biosynthesis and structure activity  Read more...


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Material Type: Conference publication
Document Type: Book
All Authors / Contributors: P H Bentley; R Southgate
ISBN: 0851868169 9780851868165
OCLC Number: 19352792
Description: ix, 380 pages
Contents: Recent advances in the biosynthesis of penicillins and cephalosporins, J.E.Baldwin; carbapenem and carbapenam biosynthesis in "Serratia" and "Erwinia" species, B.W.Bycroft; A-cyclopenams - the synthesis and activity of a new class of penam antibacterials, J.Christenson et al; new developments in the synthesis and SAR of several series of 2-aminothiazolyl cephalosporins, W.Durckheimer et al; synthesis, biological properties and pharmacokinetics of 7432-S, a new oral cephem, Y.Hamashima; synthesis of bicyclic B-lactams involving free-radical reactions, M.D.Bachi; synthesis and X-ray crystal structure determination of 1,3-bridged B-lactams - novel anti-Bredt B-lactams, R.M.Williams et al; lactivicin, a new type of B-lactam-like antibiotic from bacteria - chemistry and biological activity, Y.Nakao; synthesis and biological evaluation of pyrazolidinone antibacterial agents, R.J.Ternansky and S.E.Draheim; synthesis of potential inhibitors of bacterial D, D-peptidases, J.Marchand-Brynaert et al; novel carbapenems, T.N.Salzmann et al; a novel Diels-Alder approach to carbapenems, R.Bayles et al; penicillin and cephalosporins - their biosynthetic enzymes, R.D.G.Cooper; 6-hydroxyethyl penems - ten years after, G.Franceschi et al; synthesis and B-lactamase inhibitory activity of 6-substituted methylene penems, N.J.P.Broom et al; a new synthesis of penems, A.J.Barker and M.J.Jenkins; methodology for the design, synthesis and study of new B-lactam antibiotics, M.J.Miller et al; radical approaches to the synthesis of B-lactam antibiotics, J.Knight and P.J.Parsons; an efficient synthesis of (3R, 4R)-3-(1(R)-hydroxyethyl)-4-(benzoyloxy)-2-azetidinone from L-threonine and use of phenylalkoxymethyl as a novel N-protecting group, A.Afonso et al; the biosynthesis of clavulanic acid, S.W.Elson; class C B-lactamases - molecular and kinetic characteristics, J.M.Frere et al; synthesis and evaluation of a new series of 3-acyl-1-carbacephalosporins, J.A.Eudaly et al; synthesis and antibacterial activity of isocephems, J.Aszodi et al; cephalosporins - themes and variations, C.E.Newall.
Series Title: Special publication (Royal Society of Chemistry), 70.
Responsibility: edited by P.H. Bentley, R. Southgate.


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