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Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus.
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Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus.

Verfasser/in: IA Parshikov Mitgliedschaft: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.JP FreemanLay JO JrRD BegerAJ WilliamsAlle Autoren
Ausgabe/Format Artikel Artikel : Englisch
Veröffentichung:FEMS microbiology letters, 1999 Aug 1; 177(1): 131-5
Datenbank:Von MEDLINE®/PubMed®,eine Datenbank der U.S. National Library of Medicine.
Andere Datenbanken: British Library SerialsArticleFirst
Zusammenfassung:
A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified from culture extracts by high-performance liquid chromatography. The metabolite was identified by mass and nuclear  Weiterlesen…
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Dokumenttyp: Aufsatz
Alle Autoren: IA Parshikov Mitgliedschaft: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.; JP Freeman; Lay JO Jr; RD Beger; AJ Williams; JB Sutherland
ISSN:0378-1097
Sprachhinweis: English
Identifikator: 121324418
Auszeichnungen:

Abstract:

A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified from culture extracts by high-performance liquid chromatography. The metabolite was identified by mass and nuclear magnetic resonance spectrometry as 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-acetyl-1-piperazinyl)-3- quinolinecarboxylic acid.

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