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Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus.
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Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus.

Autor: IA Parshikov Afiliación: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.JP FreemanLay JO JrRD BegerAJ WilliamsTodos autores
Edición/Formato: Artículo Artículo : Inglés (eng)
Fuente:FEMS microbiology letters, 1999 Aug 01; 177(1): 131-5
Otras bases de datos: WorldCatWorldCat
Resumen:
A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified from culture extracts by high-performance liquid chromatography. The metabolite was identified by mass and nuclear  Leer más
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Detalles

Tipo de documento Artículo
Todos autores / colaboradores: IA Parshikov Afiliación: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.; JP Freeman; Lay JO Jr; RD Beger; AJ Williams; JB Sutherland
ISSN:0378-1097
Nota del idioma: English
Identificador único: 121324418
Premios:

Resumen:

A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified from culture extracts by high-performance liquid chromatography. The metabolite was identified by mass and nuclear magnetic resonance spectrometry as 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-acetyl-1-piperazinyl)-3- quinolinecarboxylic acid.

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