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Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus.
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Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus.

Auteur : IA Parshikov Affiliation : Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.JP FreemanLay JO JrRD BegerAJ WilliamsTous les auteurs
Édition/format : Article Article : Anglais
Publication :FEMS microbiology letters, 1999 Aug 1; 177(1): 131-5
Base de données :De MEDLINE®/PubMed®, une base de données de la U.S. National Library of Medicine.
Autres bases de données : British Library SerialsArticleFirst
Résumé :
A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified from culture extracts by high-performance liquid chromatography. The metabolite was identified by mass and nuclear  Lire la suite...
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Format : Article
Tous les auteurs / collaborateurs : IA Parshikov Affiliation : Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.; JP Freeman; Lay JO Jr; RD Beger; AJ Williams; JB Sutherland
ISSN :0378-1097
Note sur la langue : English
Identificateur Unique : 121324418
Récompenses :

Résumé :

A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified from culture extracts by high-performance liquid chromatography. The metabolite was identified by mass and nuclear magnetic resonance spectrometry as 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-acetyl-1-piperazinyl)-3- quinolinecarboxylic acid.

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