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Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus.
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Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus.

저자: IA Parshikov 소속: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.JP FreemanLay JO JrRD BegerAJ Williams모든 저자
판/형식: 문서 문서 : 영어
출판:FEMS microbiology letters, 1999 Aug 1; 177(1): 131-5
데이터베이스:미국 국립 의학 도서관의 데이터베이스인 MEDLINE®/PubMed®에서
다른 데이터베이스: British Library SerialsArticleFirst
요약:
A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified from culture extracts by high-performance liquid chromatography. The metabolite was identified by mass and nuclear  더 읽기…
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문서 형식: 아티클
모든 저자 / 참여자: IA Parshikov 소속: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.; JP Freeman; Lay JO Jr; RD Beger; AJ Williams; JB Sutherland
ISSN:0378-1097
언어 메모: English
고유 식별자: 121324418
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초록:

A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified from culture extracts by high-performance liquid chromatography. The metabolite was identified by mass and nuclear magnetic resonance spectrometry as 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-acetyl-1-piperazinyl)-3- quinolinecarboxylic acid.

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