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Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus.
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Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus.

作者: IA Parshikov 有關機構: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.JP FreemanLay JO JrRD BegerAJ Williams所有作者
版本/格式: 文章 文章 : 英語
刊登於:FEMS microbiology letters, 1999 Aug 1; 177(1): 131-5
資料庫:取自MEDLINE®/PubMed®,這是美國醫學圖書館的一個資料庫。
其他資料庫: British Library SerialsArticleFirst
提要:
A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified from culture extracts by high-performance liquid chromatography. The metabolite was identified by mass and nuclear  再讀一些...
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文件類型: 文章
所有的作者/貢獻者: IA Parshikov 有關機構: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.; JP Freeman; Lay JO Jr; RD Beger; AJ Williams; JB Sutherland
ISSN:0378-1097
語言註釋: English
專有的識別號: 121324418
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摘要:

A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified from culture extracts by high-performance liquid chromatography. The metabolite was identified by mass and nuclear magnetic resonance spectrometry as 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-acetyl-1-piperazinyl)-3- quinolinecarboxylic acid.

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