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Regulated cell death Part B : necroptotic, autophagic and other non-apoptotic mechanisms

Author: Avi Ashkenazi; Junying Yuan; James A Wells
Publisher: Amsterdam, Netherlands : Elsevier Academic Press, 2014.
Series: Methods in enzymology, v. 545.
Edition/Format:   Print book : English : 1st edView all editions and formats
Summary:
Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches.  Read more...
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Document Type: Book
All Authors / Contributors: Avi Ashkenazi; Junying Yuan; James A Wells
ISBN: 9780128014301 012801430X
OCLC Number: 885277085
Description: xiii, 337 pages, [26] pages of plates : illustrations (some color) ; 24 cm.
Contents: Assays for necroptosis and activity of RIP kinases --
IAP family of cell death and signaling regulators --
Activation of the NLRP3 inflammasome by proteins that signal for necroptosis --
Characterization of the ripoptosome and its components: implications for anti-inflammatory and cancer therapy --
Tools and techniques to study ligand-receptor interactions and receptor activation by TNF superfamily members --
Necrotic cell death in Caenorhabditis elegans --
Noncanonical cell death in the nematode Caenorhabditis elegans --
Autophagy and cell death in the fly --
Structural studies of death receptors --
Use of E2~ubiquitin conjugates for the characterization of ubitquitin transfer by RING E3 ligases such as the inhibitor of apoptosis proteins --
Muiltidimensional profiling in the invetigation of small-molecule-induced cell death.
Series Title: Methods in enzymology, v. 545.
Responsibility: edited by Avi Ashkenazi, James A. Wells, Junying Yuan.

Abstract:

Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. Continues the legacy of this premier serial with quality chapters authored by leaders in the field.

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