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Regulation of Hepatic Metabolism : Intra- and Intercellular Compartmentation

Author: Ronald G Thurman; Frederick C Kauffman; Kurt Jungermann
Publisher: Boston, MA : Springer US, 1986.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The liver is an exceptionally complex and diverse organ that functions both as an exocrine and an endocrine gland. It secretes bile, which contains many con stituents in addition to bile salts, and it synthesizes and releases many substances in response to the body's demands, including prohormones, albumin, clotting factors, glucose, fatty acids, and various lipoproteins. It has a dual blood supply providing a rich  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ronald G Thurman; Frederick C Kauffman; Kurt Jungermann
ISBN: 9781468450415 1468450417
OCLC Number: 851823166
Description: 1 online resource (510 pages)
Contents: I. Liver Structure --
1 Liver Structure and Innervation --
2 Hepatic Hemodynamics and Microcirculation --
II. Methods --
3 Histology and Histochemistry --
4 Immunohistochemistry --
5 Quantitative Histochemical Measurements within Sublobular Zones of the Liver Lobule --
6 Separation of Functionally Different Liver Cell Types --
7 New Micromethods for Studying Sublobular Structure and Function in the Isolated, Perfused Rat Liver --
8 Redox Scanning in the Study of Metabolic Zonation of Liver --
III. Distribution of Metabolic Functions --
9 Metabolism of Carbohydrates --
10 Metabolism of Lipids --
11 Metabolism of Amino Acids and Ammonia --
12 Lobular Oxygen Gradients: Possible Role in Alcohol-Induced Hepatotoxicity --
13 Biotransformation and Zonal Toxicity --
14 Protein Synthesis and Secretion --
15 Bile Acid Metabolism --
IV. Induction of Liver Cell Heterogeneity --
16 Zonal Signal Heterogeneity and Induction of Hepatocyte Heterogeneity --
V. Speculations and Directions for the Future --
Challenges for the Future.
Responsibility: edited by Ronald G. Thurman, Frederick C. Kauffman, Kurt Jungermann.

Abstract:

The liver contains many cell types including hepatic parachymal cells, Kiipffer cells, Ito cells, and endothelial cells. The most abundant cell type, the parenchymal cells, are biochemically and  Read more...

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