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Regulatory Aspects of Carcinogenesis and Food Additives : the Delaney Clause.

Author: Frederick Coulston
Publisher: Oxford : Elsevier Science, 1979.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Regulatory Aspects of Carcinogenesis and Food Additives: The Delaney Clause.
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Genre/Form: Electronic books
Conference papers and proceedings
Congresses
Additional Physical Format: Print version:
Coulston, Frederick.
Regulatory Aspects of Carcinogenesis and Food Additives: The Delaney Clause.
Oxford : Elsevier Science, ©1979
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Frederick Coulston
ISBN: 9780323151016 0323151019
OCLC Number: 843187801
Description: 1 online resource (424 pages)
Contents: Front Cover; Regulatory Aspects of Carcinogenesis and Food Additives: The Delaney Clause; Copyright Page; Table of Contents; PARTICIPANTS; FOREWORD; SESSION I; INTRODUCTORY REMARKS; CHAPTER 1. PUBLIC POLICY ISSUES IN REGULATING CARCINOGENS IN FOOD; REMARKS; CHAPTER2. THE DELANEY CLAUSE: AN EXPERIMENTAL POLICY DECISION THAT HAS BEEN MISINTERPRETED; REMARKS; CHAPTER3. THE REGULATION OF CARCINOGENS AT THE ENVIRONMENTAL PROTECTION AGENCY; GENERAL DISCUSSION; CHAPTER4. BY APPROPRIATE METHODS: THE DELANEY CLAUSE; I. INTRODUCTION. Ii. generally accepted criteria-significance in extrapolation of animal data to man reflecting a potential human carcinogenic hazardiii. procedures and factors that may confound proper assessment of carcinogenicity studies and data; iv. general comments on limiting factors; v. summary; references; chapter5. alternatives to be considered in benefit:risk decision-making; concepts of benefit:risk; the question of absolutes; the variable nature of risk and of benefit; alternatives; alternatives in experimental design; numerical estimates based on animal models; conclusions; references; remarks. Chapter6. decision-making issues relevant to cancer-inducing substancesgeneral discussion; session ii; chapter7. introductory remarks (session ii, morning); chapter8. the delaney clause: an idea whose time has come for a change; chapter9. the predictive value of animal tests for carcinogenicity; general discussion; chapter10. the design criteria and application of dose-response relationships to interpretation of carcinogenesis bioassay; i. introduction; ii. statement of purpose and need; iii. results; references; chapter11. the role of the endoplasmic reticulum in carcinogenesis. DETOXIFICATION AND ACTIVATION OF CHEMICALS BY MICROSOMAL ENZYMESTHE ENDOPLASMIC RETICULUM, GLYCOPROTEIN SYNTHESIS, AND MALIGNANCY; CARBENE FORMATION WITH CYTOCHROME P-450, MEMBRANE DEGRANULATION, AND PROMOTION OF CARCINOGENESIS; SPECIES DIFFERENCES IN MICROSOMAL ENZYME ACTIVITY AND IN CARCINOGENESIS; References; CHAPTER12. CHEMICALLY INDUCED TUMORS- THEIR RELATIONSHIP TO HUMAN CANCER; REFERENCES; GENERAL DISCUSSION; CHAPTER13. INTRODUCTORY REMARKS (SESSION II, AFTERNOON); CHAPTER14. METABOLISM AND PHOTODEGRADATION OF CHLORINATED HYDROCARBONS AND THEIR POTENTIAL IN CARCINOGENESIS. Chapter15. experimental procedures in the evaluation of chemical carcinogensreferences; remarks; chapter16. negative health implications of the delaney philosophy; general discussion; chapter17. the use of nonhuman primates for chemical carcinogenesis studies; introduction; methods; results; conclusions; references; general discussion; session iii; chapter18. extrapolating animal risk to humans; references; remarks; chapter19. assessments at an international level of health hazards to man of chemicals shown to be carcinogenic in laboratory animals; remarks.

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Regulatory Aspects of Carcinogenesis and Food Additives: The Delaney Clause.

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