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Replication-Competent Reporter-Expressing Viruses

Publisher: [s.l.] MDPI AG - Multidisciplinary Digital Publishing Institute 2016
Edition/Format:   Print book : Document   Computer File
Summary:
Recombinant viruses expressing reporter fluorescent or bioluminescent proteins are an excellent option to evaluate the dynamics of viral infection progression in both cultured cells and/or validated animal models of viral infection. Reporter proteins are valid surrogates for direct detection of infected cells in vitro and in vivo, without the use of secondary methodologies to identify infected cells. By eliminating  Read more...
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Material Type: Document, Internet resource
Document Type: Book, Computer File, Internet Resource
ISBN: 9783038422587 3038422584 9783038422594 3038422592
OCLC Number: 1004186154
Language Note: English
Accession No: (DE-599)GBV89780581X
Notes: IMD-Felder maschinell generiert
Description: 1 Online-Ressource (1 electronic resource (XVI, 322 p.))

Abstract:

Recombinant viruses expressing reporter fluorescent or bioluminescent proteins are an excellent option to evaluate the dynamics of viral infection progression in both cultured cells and/or validated animal models of viral infection. Reporter proteins are valid surrogates for direct detection of infected cells in vitro and in vivo, without the use of secondary methodologies to identify infected cells. By eliminating the need of secondary labeling, tractable replicating-competent, reporter-expressing viruses provide an ideal approach to monitor viral infections in real time, representing a significant advance in the study of the biology of viruses, to evaluate vaccination approaches, and to identify new therapeutics against viral infections using high-throughput screening settings. In this Special Issue "Replication-Competent Reporter-Expressing Viruses" we review replication-competent, reporter-expressing viruses belonging to different families, methods of characterization, and applications to facilitate the study of in vitro and in vivo viral infections. We also seek to discuss disadvantages and limitations associated with these reporter-expressing viruses. Finally, we provide rational future perspectives and additional avenues for the development, characterization, and applications of recombinant, reporter-expressing, competent viruses

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