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Resistance to immunotherapeutic antibodies in cancer : strategies to overcome resistance

Autor: Benjamin Bonavida
Editora: New York, NY : Springer, 2013.
Séries: Resistance to targeted anti-cancer therapeutics, v. 2
Edição/Formato   e-book : Documento : InglêsVer todas as edições e formatos
Resumo:
The current application of antibody-meditated targeted therapy against cancer has resulted in significant objective clinical responses, prolongation of survival and even cures. More than 20 mAbs have been approved for human use targeting a range of different cancers. However, a major drawback of mAb therapeutics is that a subset of patients does not initially respond and another initially responding subset develops  Ler mais...
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Detalhes

Gênero/Forma: Electronic books
Formato Físico Adicional: Printed edition:
Tipo de Material: Documento, Recurso Internet
Tipo de Documento Recursos de internet, Arquivo de computador
Todos os Autores / Contribuintes: Benjamin Bonavida
ISBN: 9781461476542 1461476542 1461476534 9781461476535
Número OCLC: 857224719
Notas: Includes index.
Descrição: 1 online resource (xiii, 202 pages) : illustrations.
Conteúdos: Resistance to Anticancer Antibodies: From Mechanisms to Solutions / Lina Reslan, Charles Dumontet --
Tumor Antigen-Specific Monoclonal Antibody-Based Immunotherapy, Cancer Initiating Cells and Disease Recurrence / Yangyang Wang, Francesco Sabbatino, Ling Yu --
Overcoming Resistance to Therapeutic Antibodies by Targeting Fc Receptors / Emily L. Williams, Sean H. Lim --
Understanding the Mechanisms of Resistance to Rituximab: Paving the Road for the Development of Therapeutic Strategies to Overcome Rituximab-Resistance / Francisco J. Hernandez-Ilizaliturri --
Tumor Resistance to Antibody-Mediated Immunotherapy and Reversal of Resistance: Rituximab as Prototype / Benjamin Bonavida --
Resistance to the Anti-EGFR Therapy, Beyond KRAS, in Patients with Metastatic Colorectal Cancer / Zacharenia Saridaki, John Souglakos --
Overcoming Resistance of Melanoma to Immunotherapy with Monoclonal Antibodies Against Checkpoints Inhibitors / Peter Hersey, Stuart Gallagher --
Strategies to Overcome TRAIL Resistance in Cancer / Simone Fulda --
Unnatural Amino Acid Antibody Conjugates as Next Generation Biologics / Vaughn Smider --
Antibody-Drug Conjugates: Can Coupling Cytotoxicity and Specificity Overcome Therapeutic Resistance? / Penelope M. Drake, David Rabuka.
Título da Série: Resistance to targeted anti-cancer therapeutics, v. 2
Responsabilidade: Benjamin Bonavida, editor.

Resumo:

This book examines antibody-mediated anti-cancer therapy, covering the use of mAbs against various cancers, developments in the molecular, biochemical and genetic mechanisms of resistance by various  Ler mais...

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