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Resistance to Immunotherapeutic Antibodies in Cancer : Strategies to Overcome Resistance

Author: Benjamin Bonavida
Publisher: New York, NY : Springer New York : Imprint: Springer, 2013.
Series: Resistance to Targeted Anti-Cancer Therapeutics, 2.
Edition/Format:   Print book : Document   Computer File : EnglishView all editions and formats
Database:WorldCat
Summary:
The current application of antibody-meditated targeted therapy against cancer has resulted in significant objective clinical responses, prolongation of survival and even cures. More than 20 mAbs have been approved for human use targeting a range of different cancers. However, a major drawback of mAb therapeutics is that a subset of patients does not initially respond and another initially responding subset develops  Read more...
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Additional Physical Format: Printed edition:
Resistance to Immunotherapeutic Antibodies in Cancer
Material Type: Document
Document Type: Book, Computer File
All Authors / Contributors: Benjamin Bonavida
ISBN: 9781461476542 1461476542
OCLC Number: 940640501
Description: 1 online resource (XIII, 202 p. 29 illus., 15 illus. in color.) online resource.
Contents: â Part I. Immunotherapy with monoclonal antibodies (mAbs) against various cancers1.Introduction and generation of chimeric and humanized mAbs 2. mAbs targeted against cancer cells and antibodies targeted against the tumor microenvironment 3. Antibodies directed against different major cancers: Effects when used alone or in combination with drugs 4. Mechanisms of antibodies-mediated responses, in vitro and in vivo Part II. Development of resistance to mAbs 5. Molecular Pathways 6. Molecular Signatures 7. Identification of resistance targets for intervention Part III. Agents that can sensitize resistant tumor cells to mAbs 8. Various chemicals that can sensitize resitant tumor cells 9. Other mAbs 10. Proteasome inhibitors Part IV. Novel mAbs to overcome resistance 11. Divalent mAbs 12. Antibodies coupled to chemical inhibitors 13. Antibodies coupled to cytokines 14. Nanoparticles with mAbs â
Series Title: Resistance to Targeted Anti-Cancer Therapeutics, 2.
Responsibility: edited by Benjamin Bonavida.
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Abstract:

This book examines antibody-mediated anti-cancer therapy, covering the use of mAbs against various cancers, developments in the molecular, biochemical and genetic mechanisms of resistance by various  Read more...

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