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The responses of animals inhaling nitrogen dioxide for single, short-term exposures

Author: Theophilus Carson; Mitchell J Rosenholtz; Frank T Wilinski; Aeronautical Systems Division (U.S.).; U.S. Army Chemical Research and Development Laboratories.
Publisher: Wright-Patterson Air Force Base, Ohio, Biomedical Laboratory, Air Force Systems Command, Aeronautical Systems Division, Air Force Systems Command, United States Air Force, 1961.
Series: ASD technical report, 61-525.
Edition/Format:   Book : National government publication : English
Database:WorldCat
Summary:
These experiments were designed to study the effects of NO2 at various concentration levels below the LC50 (Lethal Concentration 50) for single, short-exposure periods to obtain concentrations causing minimal effects to animals. Rats and rabbits were exposed to various concentrations of NO2 for 5 to 60 minutes and the LC50's calculated. In addition, rats and dogs were exposed for single 5 to 60 minute periods to  Read more...
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Details

Material Type: Government publication, National government publication
Document Type: Book
All Authors / Contributors: Theophilus Carson; Mitchell J Rosenholtz; Frank T Wilinski; Aeronautical Systems Division (U.S.).; U.S. Army Chemical Research and Development Laboratories.
OCLC Number: 438877987
Notes: "October 1961."
AD 268216. Cover stamp.
Research supported by the United States Air Force, Aerospace Medical Laboratory and performed by the U. S. Army Chemical Research and Development Laboratories, Army Chemical Center, Maryland.
Description: iii, 11 p. : 28 cm.
Series Title: ASD technical report, 61-525.
Responsibility: Theophilus Carson, Mitchell J. Rosenholtz, Frank T. Wilinski.

Abstract:

These experiments were designed to study the effects of NO2 at various concentration levels below the LC50 (Lethal Concentration 50) for single, short-exposure periods to obtain concentrations causing minimal effects to animals. Rats and rabbits were exposed to various concentrations of NO2 for 5 to 60 minutes and the LC50's calculated. In addition, rats and dogs were exposed for single 5 to 60 minute periods to various concentrations of NO2 below the rat LC50's. Toxic signs, pathologic changes in the lung and lung-to-body weight ratios correlated directly with the severity of exposure to NO2. Dogs showed only mild toxic signs at concentrations causing pulmonary edema in rats. Based on lung-to-body weight ratios and pathologic changes found, the concentrations of NO2 at which minimal effects found were 104, 65, and 28 ppm for 5, 15, and 60 minutes, respectively.

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