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Reverse costimulation in the treatment of infectious diseases

Author: Manzoor Ahmad Mir
Publisher: New York : Nova Science Publishers, 2014.
Series: Allergies and infectious diseases.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Cancer is one of the most prominent causes of mortality in children and adults causing about 9 million deaths annually, is a major health problem worldwide. The transformation of normal cells to cancer cells may arise due to dysregulation of oncogenes, tumor suppressors and/or stability genes. These transformed cells are sensed by the cells of the immune system, especially T cells, through specific receptors for an  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Mir, Manzoor Ahmad, author.
Reverse costimulation in the treatment of infectious diseases
(OCoLC)866584513
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Manzoor Ahmad Mir
ISBN: 9781629482132 1629482137
OCLC Number: 869544530
Description: 1 online resource.
Contents: COSTIMULATION IMMUNOTHERAPY FOR AUTOIMMUNITY, TRANSPLANTATION AND LYMPHOMAS; COSTIMULATION IMMUNOTHERAPY FOR AUTOIMMUNITY, TRANSPLANTATION AND LYMPHOMAS; Library of Congress Cataloging-in-Publication Data; Dedicated to Our Beloved Mentor; Contents; Preface; Acknowledgment; About the Author; Chapter I Regulation of Immune System by Costimulatory Molecules; Abstract; Introduction; The B7 Family of Costimulatory Ligands; CD80 Costimulatory Molecule; CD86 Costimulatory Molecule; CD80 and CD86 Binding Kinetics to CD28 and CTLA-4; Different Oligomeric States of CD80 and CD86. CD80 and CD86 Expression KineticsRole of CD80/CD86 in Response to Bacterial Infection; PDL-1/B7-H1 Costimulatory Molecule; B7-H2/B7RP-1/Licos Costimulatory Molecule; B7-DC/PDL-2 Costimulatory Molecule; B7-H3 Costimulatory Molecule; B7-H4 or B7x/B7S1 Costimulatory Molecule; B7 Family of Receptors and Their Homologues; CD28 Molecule; Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) Molecule; Reverse Costimulation through CTLA-4; ICOS (Inducible Costimulator Molecule); The Programmed Death-1 (PD-1); CD40 Costimulatory Molecule; CD40L/CD154 Costimulatory Molecule; CD40L/CD40 Interactions. CD40-CD40-L Interactionin M. Tuberculosis InfectionConclusion; References; Chapter II Costimulatory Pathways in Transplantation Therapeutics; Abstract; Introduction; Transplantation Tolerance; Costimulatory Blockade and the Mixed Chimerism Approach; Clinical Translation of Costimulatory Blockade; Harnessing Negative Costimulatory Pathways; Costimulation As Therapeutic Approach for Graft VS Host Disease; CD28/ICOS/PD-1; Costimulatory in Models of Transplantation; CTLA-4 in Models of Transplantation; Belacept a Modified Version of CTLA4 in Kidney Transplantation. PD-1: PD-L1/PD-L2 in Models of TransplantationPD-1 Pathway in Human Studies of Transplantation; B7-H3 in Models of Transplantation; B7-H4 in Models of Transplantation; BTLA in Models of Transplantation; Immunological Barriers to Effective Costimulation Blockade; Immunosuppressive Agents and Their Targets; Conclusion; References; Chapter III Costimulation in the Treatment of Autoimmune Diseases; Abstract; Introduction; Costimulation and Autoimmunity; CD28/CTLA4 and Their Ligands CD80/CD86; CD28 and B7 Families in Regulation of Autoimmunity; Co-Stimulatory Blockade in Human Autoimmune Diseases. Alteration of B7/CD28/CTLA4 As Potential Therapy for AutoimmunityPotential Therapeutic Targets Associated with B7/CD28/CTLA-4; CD40-CD40 in Autoimmunity; CD40 and Autoimmune Thyroiditis; CD40 and Type 1 Diabetes (T1d); CD40 and Neuroinflammatory Diseases; CD40 and Rheumatoid Arthritis (RA); CD40 and Systemic Lupus Erythematosus (SLE); PD-1-PDL1 and PDL2 Pathways in Autoimmunity; CD44 Isoforms; Icos Pathways Regulate Autoimmunity; BTLA4-HVEM Pathway in Autoimmune Diseases; Regulatory T Cells in Autoimmunity; Conclusion; References; Chapter IV Costimulation in the Treatment of Lymphomas.
Series Title: Allergies and infectious diseases.
Responsibility: Manzoor Ahmad Mir.

Abstract:

Cancer is one of the most prominent causes of mortality in children and adults causing about 9 million deaths annually, is a major health problem worldwide. The transformation of normal cells to cancer cells may arise due to dysregulation of oncogenes, tumor suppressors and/or stability genes. These transformed cells are sensed by the cells of the immune system, especially T cells, through specific receptors for an effective immune response. But unfortunately even after the interaction with T cells, an effective immune response is not generated. Considering the importance of costimulation in t.

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