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Reverse transcriptase inhibitors in HIV/AIDS therapy

Author: Gail Skowron; Richard C Ogden
Publisher: Totowa, N.J. : Humana Press, ©2006.
Series: Infectious disease (Totowa, N.J.)
Edition/Format:   eBook : Document : EnglishView all editions and formats
Publication:Springer e-books
Summary:
Despite significant pharmacological advances, the backbone of the most highly active antiretroviral therapy regimens for controlling HIV/AIDS is still a combination of reverse transcriptase inhibitors (RTIs) first discovered in the late 1980s. In Reverse Transcriptase Inhibitors in HIV/AIDS Therapy, leading experts in AIDS/HIV drug discovery and development review all aspects of RTIs (nucleosides, nucleotides, and  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Reverse transcriptase inhibitors in HIV/AIDS therapy.
Totowa, N.J. : Humana Press, ©2006
(DLC) 2005033190
(OCoLC)62342737
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Gail Skowron; Richard C Ogden
ISBN: 1588296490 1597450855 9781597450850 9781588296498
OCLC Number: 174134757
Description: 1 online resource (xiii, 527 pages) : illustrations.
Contents: Structural studies on HIV reverse transcriptase related to drug discovery / David K. Stammers and Jingshan Ren --
Zidovudine, lamivudine, and abacavir / Monica Carten and Harold Kessler --
Stavudine, didanosine, and zalcitabine / Gail Skowron, Sapna Chowdhry and Michael R. Stevens --
Emtricitabine / Gail Skowron, Jeffrey Bratberg and Rudi Pauwels --
Nucleotide analogs / Craig J. Hoesley --
Resistance to nucleoside and nucleotide reverse transcriptase inhibitors / Nancy Shulman and Mark Winters --
Pharmacokinetics of reverse transcriptase inhibitors / Patrick Hoggard [and others] --
Peripheral neuropathy associated with nucleoside reverse transcriptase inhibitor therapy / Bruce A. Cohen and Russell Bartt --
Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: a pathophysiological perspective / William Lewis --
Mitochondrial toxicity and lipodystrophy / Grace McComsey --
Nevirapine / David Asmuth and Richard Pollard --
Efavirenz / Graeme J. Moyle and Brian Conway --
Delavirdine / Brian Conway --
Resistance to non-nucleoside reverse transcriptase inhibitors / F. Ramzi Asfour and Richard Haubrich --
Vertical transmission of HIV and therapeutic interventions / Susan Cu-Uvin, Arlene Bardeguez and Carla Chibwesha --
New reverse transcriptase inhibitors in development / Rudi Pauwels --
Antiretroviral drugs for millions / Allan Ronald, Ellie Katabira and Merle Sande.
Series Title: Infectious disease (Totowa, N.J.)
Responsibility: edited by Gail Skowron, Richard Ogden ; foreword by Joep M.A. Lange.
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Abstract:

A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and  Read more...

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