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Reversible Ligand Binding to Proteins : Experiment and Theory.

Author: Andrea Bellelli; Jannette Carey
Publisher: Newark : John Wiley & Sons, Incorporated, 2017.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Bellelli, Andrea.
Reversible Ligand Binding to Proteins : Experiment and Theory.
Newark : John Wiley & Sons, Incorporated, ©2017
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Andrea Bellelli; Jannette Carey
ISBN: 9781119238478 1119238471
OCLC Number: 1009270602
Notes: ""Appendix 4.1 Statistical Distribution of the Ligand Among the Binding Sites: Statistical Factors""
Description: 1 online resource (312 pages)
Contents: ""Title Page ""; ""Copyright Page""; ""Contents""; ""Preface""; ""Acknowledgments""; ""Part I Ligand Binding to Single Binding Site Targets""; ""Chapter 1 Theory of Ligand Binding to Monomeric Proteins ""; ""1.1 Importance of Ligand-Binding Phenomena in Biology ""; ""1.2 Preliminary Requirements for Ligandâ#x80;#x90;Binding Study""; ""1.3 Chemical Equilibrium and the Law of Mass Action""; ""1.4 The Hyperbolic and Sigmoidal Representations of the Ligand-Binding Isotherms ""; ""1.5 The Important Concept of X1/2""; ""1.6 Other Representations of the Ligandâ#x80;#x90;Binding Isotherm"" ""1.7 Effect of Temperature: Thermodynamic Relationships""""1.8 Replacement Reactions: Competitive Ligands""; ""1.9 Heterotropic Linkage: Non-Competitive Binding of Two Ligands ""; ""1.10 Allostery and Allosteric Phenomena in Monomeric Proteins""; ""1.11 The Special Case of Cys Ligands (and Similar Reactions)""; ""1.12 Other Special Cases""; ""References""; ""Chapter 2 Ligand-Binding Kinetics for Single-Site Proteins ""; ""2.1 Basic Concepts of Chemical Kinetics: Irreversible Reactions""; ""2.2 Reversible Reactions: Equilibrium and Kinetics""; ""2.3 More Complex Kinetic Mechanisms"" ""2.4 Reactions with Molecularity Higher Than Two""""2.5 Classical Methods for the Study of Ligand-Binding Kinetics ""; ""2.6 Photochemical Kinetic Methods""; ""2.7 The Kinetics of Replacement Reactions""; ""References""; ""Appendix to Chapter 2: Principles of Data Analysis""; ""Chapter 3 Practical Considerations and Commonly Encountered Problems ""; ""3.1 Design of the Experiment: The Free Ligand Concentration""; ""3.2 The Signal and the Concentration of the Target""; ""3.3 Test of the Reversibility of the Reaction""; ""3.4 Frequent Abuses of the Concept of X1/2"" ""3.5 Two Common Problems: Protein Precipitation and Baseline Shifts""""3.6 Low-Affinity Ligands ""; ""3.7 High-Affinity Ligands ""; ""3.8 Determination of Binding Stoichiometry""; ""3.9 Ligands Occupying a Thermodynamic Phase Different from the Protein""; ""3.10 Mixtures of Isoforms""; ""3.11 Poor or Absent Signal""; ""References""; ""PART II Ligand Binding to Multiple Binding Site Proteins""; ""Chapter 4 Proteins with Multiple Binding Sites ""; ""4.1 Multiple Binding Sites: Determination of the Binding Stoichiometry"" ""4.2 The Binding Polynomial of a Homooligomeric Protein Made Up of Identical Subunits""""4.3 Intramolecular Heterogeneity""; ""4.4 Oligomeric Proteins with Interacting Binding Events: Homotropic Linkage""; ""4.5 Cooperativity: Biochemistry and Physiology""; ""4.6 Allostery and Symmetry: The Allosteric Model of Cooperativity""; ""4.7 Two Alternative Concepts of Cooperativity""; ""4.8 Ligand Replacement in Oligomeric Proteins""; ""4.9 Heterotropic Linkage in Multimeric Proteins""; ""4.10 Heterotropic Linkage and the Allosteric Model""; ""References""

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