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|Additional Physical Format:||Print version:
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 163.
Dordrecht : Springer, ©2012
|Material Type:||Document, Internet resource|
|Document Type:||Internet Resource, Computer File|
|All Authors / Contributors:||
Bernd Nilius; Susan G Amara; Thomas Gudermann; Reinhard Jahn; Roland Lill; Stefan Offermanns; Ole H Petersen
|Notes:||3.1.4 Non-ion Selective Channels.|
|Description:||1 online resource (137 pages).|
|Contents:||Reviews of Physiology, Biochemistry and Pharmacology 163; Contents; Induced Pluripotent Stem Cells in Cardiovascular Research; 1 Introduction; 2 Induced Pluripotent Stem Cells; 2.1 A New Type of Pluripotent Stem Cells; 2.2 Generation of Human Induced Pluripotent Stem Cells; 2.3 Differentiation Protocols; 2.4 The Concept of Patient-Specific Stem Cells; 3 A New Type of Disease Models; 3.1 General Considerations; 3.2 Long-QT Syndrome as a Paradigm for iPSC-Based Disease Modeling; 3.3 Other Promising Target Diseases; 3.3.1 Catecholaminergic Polymorphic Ventricular Tachycardia. 3.3.2 Short-QT Syndrome3.3.3 Brugada Syndrome; 3.3.4 Dilated Cardiomyopathy; 3.3.5 Hypertrophic Cardiomyopathy; 3.3.6 Arrhythmogenic Right Ventricular Cardiomyopathy; 3.3.7 Multifactorial Diseases; 3.4 Outlook; 4 Applications in Drug Development; 4.1 Drug Screening; 4.2 Drug Safety; 5 Patient-Specific Therapy; 6 A New Tool for Genetic Investigations; 7 Cardiac Cell Therapy; 7.1 Transplantation of Undifferentiated iPSC; 7.2 Transplantation of iPSC-Derived Cardiomyocytes; 7.3 Transplantation of iPSC-Derived Cardiac Progenitors; 7.4 Safety Issues; 8 Concluding Remarks; References. TRPs in the Brain1 The Transient Receptor Potential Family of Cation Channels; 2 Clues for the Role of TRP Channels in the Development of the Brain and Neuronal Function; 2.1 Axon Guidance, Growth Cone Tuning and TRPC ́s; 2.2 A Role for TRP Channels in Synaptic Plasticity and Behaviour; 2.3 TRP Channels as Players in Neuronal Activity; 3 TRP Channels Cause Neurological Diseases; 3.1 TRP Channels Could Play a Role in Disease Mechanisms; 3.2 TRPs Channels in Brain Injury and Stroke; 3.3 TRPs, Schizophrenia and Bipolar Disorders; 3.4 Lessons from KO Mice; 3.5 Lessons from Human Disease. 4 ConclusionReferences; The Channel Physiology of the Skin; 1 The Skin and Its Key Functions; 1.1 The Functional Anatomy of the Skin; 1.2 Key Functions of the Skin; 1.2.1 Barrier Functions; The Physical-Chemical Barrier; The (Micro)biological Barrier; The Immunological Barrier; The Barrier Regeneration; Related Cutaneous Diseases; 1.2.2 Neuroendocrine Functions; 1.2.3 Other Functions; 2 A Short Introduction of Ion and Non-ion Selective Channels; 2.1 Ion Channels; 2.1.1 Voltage-Gated Ion Channels; 2.1.2 Ligand-Gated Ion Channels; 2.1.3 Transient Receptor Potential Ion Channels. 2.1.4 Other Ion Channels2.2 Non-ion Selective Channels; 2.2.1 Aquaporins; 2.2.2 Connexins; 2.2.3 Pannexins; 3 Roles of Channels in Skin Physiology and in Certain Dermatoses; 3.1 Roles of Channels in Epidermal Physical-Chemical Barrier Functions and Barrier Recovery; 3.1.1 Voltage-Gated Channels; Voltage-Gated Ca2+-Channels; Ca2+-Activated K+-Channels; 3.1.2 Ligand-Gated channels; nAChRs; Ionotropic Glutamate Receptors; P2X Receptors; 5-HT3 Receptors; GABAA Receptors; Glycine Receptors; 3.1.3 TRP Channels; TRPV1; TRPV3 and TRPV4; TRPV6; TRPC Channels; TRPA1; TRPM Channels.|
|Series Title:||Reviews of Physiology, Biochemistry and Pharmacology.|