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Ribozymes and RNA catalysis

Author: David M J Lilley; Fritz Eckstein; Royal Society of Chemistry (Great Britain)
Publisher: Cambridge : RSC Pub., 2008.
Series: RSC biomolecular sciences.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:
Takes the reader through the origins of catalysis in RNA and necessarily includes significant discussion of structure and folding. The main focus of the book concerns chemical mechanism with extensive comment on how, despite the importance of RNA catalysis in the cell, its origins are still poorly understood and often controversial. The reader is given an outline of the important role of RNA catalysis in many  Read more...
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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: David M J Lilley; Fritz Eckstein; Royal Society of Chemistry (Great Britain)
ISBN: 9780854042531 0854042539
OCLC Number: 183914445
Description: xx, 318 pages : illustrations (some color) ; 25 cm.
Contents: Ribozymes and RNA catalysis : introduction and primer --
Proton transfer in ribozyme catalysis --
Finding the Hammerhead ribozyme active site --
Hammerhead ribozyme crystal structures and catalysis --
The Hairpin and Varkud satellite ribozymes --
Catalytic mechanism of the HDV ribozyme --
Mammalian self-cleaving ribozymes --
The structure and action of glmS ribozymes --
A structural analysis of Ribonuclease P --
Group I introns : biochemical and crystallographic characterization of the active site structure --
Group II introns : catalysts for splicing, genomic change and evolution --
The GIR1 branching ribozyme --
Is the spliceosome a ribozyme? --
Peptidyl transferase mechanism : the ribosome as a ribozyme --
Folding mechanisms of Group I ribozymes.
Series Title: RSC biomolecular sciences.
Responsibility: edited by David M.J. Lilley, Fritz Eckstein.

Abstract:

The emphasis of this book concerns the origins of catalysis in RNA and is well suited for undergraduates, postgraduates and researchers in catalytic chemistry.  Read more...

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"...this is a book that certainly should be foundin every laboratory investigating RNA catalysis and can serveas a valuable reference for anyone teaching modern biochemistry." Journal of the American Read more...

 
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