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RNA interference

Author: Patrick J Paddison; P K Vogt
Publisher: Berlin : Springer, ©2008.
Series: Current topics in microbiology and immunology, 320.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
In the last few years the major effect that RNAi has had in invertebrate systems like C.elegans and drosophila is beginning to take hold in mammalian systems through both single gene knockdown experiments and genome-scale screens. In the next decade, there will no doubt be both notable successes and failures as we attempt to apply this genetic tool to various biological problems for the first time in academia and  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
RNA interference.
Berlin : Springer, ©2008
(OCoLC)190776760
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Patrick J Paddison; P K Vogt
ISBN: 9783540751571 3540751572 9783540751564 3540751564 9786611179496 6611179496
OCLC Number: 233973520
Description: 1 online resource (viii, 273 pages) : illustrations (some color).
Contents: RNA interference in mammalian cell systems / Patrick J. Paddison --
RNAi pathway in C. elegans: the argonautes and collaborators / Marie-Eve L. Boisvert and Martin J. Simard --
Genetics and biochemistry of RNAi in drosophila / Harsh H. Kavi [and others] --
Role of dicer in posttranscriptional RNA silencing / Lukasz Jaskiewicz and Witold Filipowicz --
The mechanism of RNase III action: how dicer dices / Xinhua Ji --
MicroRNA metabolism in plants / Xuemei Chen --
Structure-function relationships among RNA-dependent RNA polymerases / Kenneth K.-S. Ng, Jamie J. Arnold, and Craig E. Cameron --
RNAi-mediated chromatin silencing in fission yeast / Sharon A. White and Robin C. Allshire --
A role for RNAi in heterochromatin formation in drosophila / Nicole C. Riddle and Sarah C.R. Elgin --
RNA mediated transcriptional gene silencing in human cells / Kevin V. Morris --
RNA silencing in mammalian oocytes and early embryos / Petr Svoboda --
Identifying human microRNAs / Isaac Bentwich.
Series Title: Current topics in microbiology and immunology, 320.
Other Titles: Ribonucleic acid interference
Responsibility: Patrick J. Paddison, Peter K. Vogt, editors.

Abstract:

In the last few years the major effect that RNAi has had in invertebrate systems is beginning to take hold in mammalian systems through both single gene knockdown experiments and genome-scale  Read more...

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