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Robustness and evolvability in living systems

Author: Andreas Wagner
Publisher: Princeton, N.J. ; Woodstock : Princeton University Press, 2007.
Series: Princeton studies in complexity.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:

Explores why genetic changes do not cause organisms to fail catastrophically and how evolution shapes organisms' robustness. This book looks at this problem, starting with the alphabet of DNA, the  Read more...

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Andreas Wagner
ISBN: 9780691134048 0691134049
OCLC Number: 132299281
Notes: Originally published: 2005.
Description: pages cm.
Contents: List of Figures ix Acknowledgments xiii Chapter 1: Introduction 1 PART I: ROBUSTNESS BELOW THE GENE LEVEL 13 Chapter 2: The Genetic Alphabet 15 Chapter 3: The Genetic Code 25 Chapter 4: RNA Structure 39 Chapter 5: Proteins and Point Mutations 62 Chapter 6: Proteins and Recombination 78 PART II: ROBUSTNESS ABOVE THE GENE LEVEL 91 Chapter 7: Regulatory DNA Regions and Their Reorganization in Evolution 93 Chapter 8: Metabolic Pathways 104 Chapter 9: Metabolic Networks 120 Chapter 10: Drosophila Segmentation and Other Gene Regulatory Networks 143 Chapter 11: Phenotypic Traits, Cryptic Variation, and Human Diseases 161 Chapter 12: The Many Ways of Building the Same Body 175 PART III: COMMON PRINCIPLES 193 Chapter 13: Neutral Spaces 195 Chapter 14: Evolvability and Neutral Mutations 217 Chapter 15: Redundancy of Parts or Distributed Robustness? 228 Chapter 16: Robustness as an Evolved Adaptation to Mutations 247 Chapter 17: Robustness as an Evolved Adaptation to Environmental Change and Noise 270 Chapter 18: Robustness and Fragility: Advantages to Variation and Trade-offs 281 PART IV: ROBUSTNESS BEYOND THE ORGANISM 295 Chapter 19: Robustness in Natural Systems and Self-Organization 297 Chapter 20: Robustness in Man-made Systems 310 Epilogue: Seven Open Questions for Systems Biology 321 Bibliography 323 Index 359
Series Title: Princeton studies in complexity.
Responsibility: Andreas Wagner.

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"Wagner's treatise is more than good biology; it is also very interesting biology. The picture is painted by talented hands... If I have a favorite aspect of the book, it is the meticulous yet Read more...

 
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