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The role of glucocorticoid receptor polymorphisms and glucocorticoid sensitivity in human obesity and the metabolic syndrome

Author: Akheel Ahmed Syed; University of Newcastle upon Tyne. School of Clinical Medical Sciences.; University of Newcastle upon Tyne.
Publisher: Newcastle upon Tyne : University of Newcastle upon Tyne, 2008.
Dissertation: Ph. D. University of Newcastle upon Tyne 2008
Edition/Format:   Thesis/dissertation : Thesis/dissertation : English
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Material Type: Thesis/dissertation
Document Type: Book
All Authors / Contributors: Akheel Ahmed Syed; University of Newcastle upon Tyne. School of Clinical Medical Sciences.; University of Newcastle upon Tyne.
OCLC Number: 213271125
Description: 217 pages : illustrations ; 30 cm
Responsibility: by Akheel A. Syed.

Table of Contents:

by aas (WorldCat user on 2008-08-28)

Acknowledgements Abstract Contents List of tables List of figures Abbreviations Introduction The metabolic syndrome Thrifty genotype Glucocorticoids and the metabolic syndrome The glucocorticoid receptor Factors that modulate GR action The GR gene Summary Aims Methods: an overview Genetic association studies Study population Genetic analysis Statistical analysis Glucocorticoid sensitivity in obesity Study population Glucocorticoid sensitivity in vitro Statistical analysis N363S polymorphism Introduction Methods Results Discussion Exon 9β polymorphism Introduction Methods Results Discussion Intronic polymorphisms Introduction Methods Results Discussion Glucocorticoid sensitivity in obesity Introduction Participants and methods Results Discussion Conclusions Genetic association studies Glucocorticoid sensitivity in obesity References Appendix Supplementary figures Supplementary tables Information sheet for GC-sensitivity participants Clinical characteristics of GC-sensitivity participants Procedures Skin biopsy Primary cell culture Harvesting primary cultures Secondary cell culture Freezing cells Publications

Notes:

by aas (WorldCat user on 2008-08-28)

Full text may be requested at http://DrSyed.org/PhD.aspx

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