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The role of microtubules in cell biology, neurobiology, and oncology

Author: Antonio Tito Fojo
Publisher: Totowa, N.J. : Humana Press, ©2008.
Series: Cancer drug discovery and development.
Edition/Format:   Print book : EnglishView all editions and formats

This book presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects  Read more...


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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Antonio Tito Fojo
ISBN: 9781588292940 1588292940
OCLC Number: 232612212
Description: xviii, 587 pages : illustrations ; 27 cm + 1 CD-ROM (4 3/4 in.).
Contents: 1. An Overview of Compounds that Interact with Tubulin and their Effects on Microtubule Assembly. Ernest Hamel2. Molecular Mechanisms of Micotubule Acting Cancer Drugs.J. J. Correia and S. Lobert3. Microtubule Dynamics: Mechanisms and Regulation by Microtubule-Associated Proteins and Drugs in vitro and in cellsMary Ann Jordan and Leslie Wilson4. Microtubule Associated Proteins (MAPs) and Microtubule Interacting Proteins: Regulators of Microtubule DynamicsMaria Kavallaris, Sima Don, Nicole M. Verrills5. The Post-Translational Modifications of TubulinRichard F. Luduena, and Asok Banerjee6. The Isotypes of Tubulin: Distribution and Functional SignificanceRichard F. Luduena, and Asok Banerjee7. The Tubulin SuperfamilyRichard F. Luduena, and Asok Banerjee8. Tubulin Proteomics in CancerPascal Verdier Pinard, Fang Wang, Ruth Hogue Angeletti , Susan Band Horwitz, and George A. Orr9. Tubulin and Microtubule StructuresEva Nogales and Kenneth H. Downing10. Destabilizing Agents: Peptides and Depsipeptides Lee M. Greenberger and Frank Loganzo11. Molecular Features of the Interaction of Colchicine and Related Structures with TubulinSusan L. Bane12. Antimicrotubule Agents that Bind Covalently to TubulinDan L. Sackett13. Microtubule Stabilizing AgentsSusan Band Horwitz and Tito Fojo14. Mechanisms of Resistance to Drugs that Interfere with Microtubule AssemblyFernando Cabral15. Resistance to Microtubule Targeting Drugs: Part IIParaskevi Giannakakou and James P. Snyder16. Microtubule Stabilizing Agent in Clinical Oncology: The TaxanesChris H. Takimoto and Muralidhar Beeram17. Investigational anti-cancer agents targeting the microtubule.Lyudmila A. Vereshchagina, Orit Scharf, and A. Dimitrios Colevas18. MicrotubuleDamaging Agents and ApoptosisManon Carre and Diane Brauger 19. Microtubule targeting agents and the tumor vasculatureRaffaella. Giavazzi, K. Bonezzi and Giulia Taraboletti20. Neurodegenerative Diseases: Tau Proteins in Neurodegenerative Diseases Other Than Alzheimer's DiseaseAndre Delacourte, Nicolas Sergeant and Luc Buee21. Structure, Function and Regulation of the Microtubule Associated Protein TauJanis Bunker and Stuart C. Feinstein
Series Title: Cancer drug discovery and development.
Responsibility: edited by Tito Fojo.
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From the reviews:"This book is appropriate for laboratories with an interest in the biology of microtubules ... . Each chapter is nicely illustrated, well referenced, and offers a timely evaluation Read more...

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