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Role of Smad-interacting protein 1 (Sip1/Zfhx1b) in the development of the cerebral cortex

Author: Amaya Miquelajáuregui Graf
Publisher: Göttingen Niedersächsische Staats- und Universitätsbibliothek
Edition/Format:   Computer file : EnglishView all editions and formats
Summary:
Smad-interacting protein 1 (Sip1/Zfhx1b) is a transcription factor that has been previously implicated in TGF-ß/BMP signaling and in the etiology of the Mowat-Wilson syndrome. The expression of Sip1 was documented during mouse corticogenesis. The cortex-specific ablation of Sip1 resulted in the lack of hippocampus and dentate gyrus and in severe cortical lamination defects. Sip1 mutant mice exhibited cell death of  Read more...
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Material Type: Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Amaya Miquelajáuregui Graf
OCLC Number: 837100781
Description: Online Ressource (PDF-Datei: 98 S., 8.700 KB) Ill., graph. Darst.
Responsibility: vorgelegt von Amaya Miquelajáuregui Graf

Abstract:

Smad-interacting protein 1 (Sip1/Zfhx1b) is a transcription factor that has been previously implicated in TGF-ß/BMP signaling and in the etiology of the Mowat-Wilson syndrome. The expression of Sip1 was documented during mouse corticogenesis. The cortex-specific ablation of Sip1 resulted in the lack of hippocampus and dentate gyrus and in severe cortical lamination defects. Sip1 mutant mice exhibited cell death of differentiating cells and decreased proliferation in the region of the prospective hippocampus and dentate gyrus. In Sip1 mutants, the expression of the Wnt antagonist Sfrp1 was ectopically activated in the developing hippocampus and strongly up-regulated in post-mitotic cortical areas. The activity of the non-canonical Wnt effector, JNK, was inhibited in the prospective hippocampus of Sip1 mutants ...

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