Don Tillman, professor of genetics, has never been on a second date. He is a man who can count all his friends on the fingers of one hand, whose lifelong difficulty with social rituals has convinced him that he is simply not wired for romance. So when an acquaintance informs him that he would make a "wonderful" husband, his first reaction is shock. Yet he must concede to the statistical probability that there is someone for everyone, and he embarks upon The Wife Project. In the orderly, evidence-based manner with which he approaches all things, Don sets out to find the perfect partner. He sets up a project designed to find him the perfect wife, starting with a questionnaire that has to be adjusted a little as he goes along. She will be punctual and logical, most definitely not a barmaid, a smoker, a drinker, or a late-arriver. Then he meets Rosie Jarman, who is everything he's not looking for in a wife. Rosie is all these things. She is also beguiling, fiery, intelligent, and on a quest of her own. She is looking for her biological father, a search that a certain DNA expert might be able to help her with. Don's Wife Project takes a back burner to the Father Project and an unlikely relationship blooms, forcing the scientifically minded geneticist to confront the spontaneous whirlwind that is Rosie, and the realization that love is not always what looks good on paper.