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Sarcopenia age-related muscle wasting and weakness : mechanisms and treatments

Author: Gordon S Lynch
Publisher: Dordrecht : Springer, 2010.
Edition/Format:   eBook : Document : EnglishView all editions and formats

Some of the most serious consequences of aging are its effects on skeletal muscle. This book provides the latest state-of-the-art information on sarcopenia. It includes contributions from some of  Read more...


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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Gordon S Lynch
OCLC Number: 698590402
Description: 1 online resource (xiii, 479 pages) : illustrations
Contents: 1.Overview.- 2. Molecular mechanisms of muscle wasting in cancer and ageing: cachexia versus sarcopenia.- 3. Age-related remodeling of neuromuscular junctions.- 4.Motor unit remodeling during aging.- 5. Age-related decline in actomyosin structure and function.- 6. Excitation-contraction coupling in aged skeletal muscle.- 7. Mitochondrial function in aging skeletal muscle.- 8. Fibrosis and skeletal muscle aging.- 9. Nuclear apoptosis and sarcopenia.- 10. Age-related changes in the molecular regulation of skeletal muscle mass.- 11. Genetic variation and skeletal muscle traits: implications for sarcopenia.- 12. Proteomic profiling of aged skeletal muscle.- 13. Aging, exercise and muscle protein metabolism.- 14. Reactive oxygen species generation and skeletal muscle wasting - implications for sarcopenia.- 15. Exercise as a countermeasure for sarcopenia.- 16. Role of contraction-induced injury in age-related muscle wasting and weakness.- 17. Role of IGF-I signaling in age-related changes in skeletal muscle.- 18. Role of myostatin and TGF-beta signaling in skeletal muscle growth and development: implications for sarcopenia.- 19. ss-Adrenergic signaling in sarcopenia and other muscle wasting disorders.
Responsibility: Gordon S. Lynch, editor.


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