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Selected Topics in Mass Spectrometry in the Biomolecular Sciences

Author: Richard M Caprioli; Antonio Malorni; Giovanni Sindona
Publisher: Dordrecht : Springer Netherlands : Imprint : Springer, 1997.
Series: NATO ASI series., Series C,, Mathematical and physical sciences ;, 504.
Edition/Format:   eBook : Bibliographic data : EnglishView all editions and formats
Summary:
Many fundamental aspects of the methods used in mass spectrometry are here presented by outstanding scientists, with reference to very recent developments. The principles and applications of electrospray, ion spray and MALDI ionization technique are presented, together with optimised GC/MS interfacing systems and tools for quantitative analysis. A comprehensive treatment of modern instrumentation for mass analysis  Read more...
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Genre/Form: Electronic books
Conference papers and proceedings
Congresses
Additional Physical Format: Printed edition:
Material Type: Bibliographic data, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Richard M Caprioli; Antonio Malorni; Giovanni Sindona
ISBN: 9789401151658 9401151652 9789401061711 9401061718
OCLC Number: 840311138
Description: 1 online resource (612 pages).
Contents: I: Methods in Mass Spectrometry --
Electrospray Ionization: Theory and Application --
Atmospheric Pressure Ionization (ESI and APCI) Theory and Application --
Matrix-Assisted Laser Desorpition-Ionization (MALDI) Mass Spectrometry: Principles and Applications --
High Sensitivity ESI/MS and MALDI MS --
Optimised GC/MS Interfacing Systems and Operating Conditions --
Quantitative Analysis by Mass Spectrometry: Some Important Considerations --
Optimization of Mass Spectrometric Ionisation Efficiency Data --
Role of Internal Energy in Mass Spectrometric Fragmentation --
Interaction of Metal Ions and Protons with Simple Biomolecules. Structure Information from Bond Energies and Entropy Effects --
A Promising Marriage Between Theory and Experiment: Density Functional Method Versus Mass Spectrometry --
II: Instrumentation for Mass Analysis and Detection --
Recent Advances in Magnet Sector Mass Spectrometry --
Quadrupole Mass Filters and Quadrupole Ion Traps --
Time-of-Flight Mass Spectrometry --
Combined Analyzer Technologies --
Fourier Transform Mass Spectrometry --
III: Application to Biomolecules --
Protein Characterization by MS in Pharmaceutical Industry. Structural Characterization of Modified Forms of Recombinant Hirudin Sequence Variant 1 and Direct Batch Analysis --
Folding Pathways of Disulphide Containing Proteins --
Integration of Chemical Modification Reactions and Mass Spectrometric Methods in Protein Characterisation --
PSD-MALDI Analysis of Peptides --
Development of a Mass Spectrometric Approach for the Characterisation of Hemoglobin Adducts --
Reactivity of Antineoplastic Drugs with Model Peptides Studied by Advanced Mass Spectrometry Methodologies --
Applications of Mass Spectrometry in Biochemical Studies of Nucleosides, Nucleotides and Nucleic Acids --
MALDI Mass Analysis of Oligonucleotides --
DNA Adducts in Human Carcinogenesis. Clues to Etiology and Mechanism --
MALDI MS of Oligo and Polysaccharides --
Mass Spectrometry of Isoeicosanoids as Novel Lipid Substances --
The Role of Mass Spectrometry in the Characterization of Plant Metabolites from Crude Extracts --
Environmental Applications of Mass Spectrometry: Toxaphene Analysis --
The Determination of Polar Compounds in the Aquatic Environment --
Some Mass Spectrometry Contributions in the Study of Cultural Heritage.
Series Title: NATO ASI series., Series C,, Mathematical and physical sciences ;, 504.
Other Titles: Proceedings of the NATO Advanced Study Institute on Mass Spectrometry in the Biomolecular Sciences, Altavilla-Milicia (PA), Italy, 7-18 July 1996
Responsibility: edited by Richard M. Caprioli, Antonio Malorni, Giovanni Sindona.

Abstract:

Proceedings of the NATO Advanced Study Institute on Mass Spectrometry in the Biomolecular Sciences, Altavilla-Milicia (PA), Italy, 7-18 July 1996  Read more...

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