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Selectins: interpreters of cell-specific carbohydrate information during inflammation.
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Selectins: interpreters of cell-specific carbohydrate information during inflammation.

Author: LA Lasky Affiliation: Department of Immunology, Genetech, Inc., South San Francisco, CA 94080.
Edition/Format: Article Article : English
Publication:Science (New York, N.Y.) 1992 Nov 6; 258(5084): 964-9
Database:From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Summary:
Although a bewildering array of cell surface carbohydrate structures have been described, the physiological relevance of any of these complex molecules has often eluded biologists. A family of cell surface glycoproteins, the "selectins," has a characteristic ability to use some of these carbohydrate structures in adhesive mechanisms that help localize leukocytes to regions of inflammation. This article will review  Read more...
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Details

Document Type: Article
All Authors / Contributors: LA Lasky Affiliation: Department of Immunology, Genetech, Inc., South San Francisco, CA 94080.
ISSN:0036-8075
Language Note: English
Unique Identifier: 116849825
Awards:

Abstract:

Although a bewildering array of cell surface carbohydrate structures have been described, the physiological relevance of any of these complex molecules has often eluded biologists. A family of cell surface glycoproteins, the "selectins," has a characteristic ability to use some of these carbohydrate structures in adhesive mechanisms that help localize leukocytes to regions of inflammation. This article will review the biology of these carbohydrate-binding adhesive proteins and discuss the potential for developing anti-inflammatory antagonists that could inhibit binding events that are selectin-mediated.

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