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Selective heat sensitivity of cancer cells

Author: A Rossi Fanelli
Publisher: Berlin ; New York : Springer-Verlag, 1977.
Series: Recent results in cancer research, 59.
Edition/Format:   Print book : EnglishView all editions and formats
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Sponsored by the Swiss League against Cancer

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Document Type: Book
All Authors / Contributors: A Rossi Fanelli
ISBN: 9780387079738 0387079734 3540079734 9783540079736
OCLC Number: 2598159
Description: xii, 189 pages : illustrations ; 25 cm.
Contents: 1. Introduction.- 2. Biochemical Aspects of Heat Sensitivity of Tumour Cells.- 1. Introduction.- 2. Selectivity of the Lethal Effect of Supranormal Temperatures on Tumour Cells.- 3. Nature of the Lesions Caused by Supranormal Temperatures in Mammalian Cells.- 4. Thermal Sensitivity and the Cell Cycle.- 5. Possible Molecular Mechanism(s) of the Heat-Induced Cell Damage.- A. Nucleic Acide and/or Proteins.- B. Membrane Systems.- 3. Actions of Hyperthermia on Tumour Cells Cultured in vitro.- 4. The Effects of Hyperthermia in Animal Tumour Systems.- 1. Introduction.- 2. Animal Tumour Models.- 3. Current Approches.- A. In vivo Methodology.- B. In vitro Methodology.- 4. The Effects of Heat on Animal Tumours.- A.Biochemical Changes.- B. Histological Changes.- C.Local Hyperthermia vs Total Body Hyperthermia.- 5. Hazards and Potentiators of Hyperthermia in the Treatment of Cancer.- A. Hazards of Hyperthermia.- B. Potentiators of Hyperthermia.- 6. Discussion.- A. Relationship Between Primary Tumours and Its Metastases and Host-Tumour Relationship.- B. Bacteria, Hyperpyrexia and the Immune System.- 7. Implications of Current Results for Human Therapy.- A. In vitro Sensitivity of Human Tumours to Hyperthermia (42 C).- B. Schedule for Heating Human Tumours in vivo.- C. Value of Animal Test Systems.- 8. Summary and Perspectives.- 5. Hyperthermic Treatment of Tumours: Experimental and Clinical Applications.- 1. Introduction.- 2. Experimental Studies.- A. Whole-Body Hyperthermia.- B. Local Hyperthermia by Perfusion on Dogs.- C. Experimental Models.- 3. Clinical Application.- A. Whole-Body Hyperthermia.- B. Local Heating.- 4. Technique.- 5. Case Report.- 6. Discussion.- 6. Whole-Body Hyperthermia. A Systemic Treatment for Disseminated Cancer.- 1. Methods of Inducing Hyperthermia.- 2. Anaesthesia During Hyperthermia.- 3. Method.- 4. Haemodynamic Response.- 5. Biochemical and Haemotological Changes.- 6. Clinical Results.- 7. Assessment of Response.- 8. Hyperthermia Alone.- 9. Case Reports.- 10. Hyperthermia in Combination with Cytotoxic Drugs.- 11. Case Reports.- 12. Hyperthermia Combined with Local Radiotherapy.- 13. Complications.- 14. Fractionation of Hyperthermia.- 15. Future Management.- 16. Summary.- 7. Hyperthermic Perfusion of Extremities for Melanoma and soft Tissue Sarcomas.- 1. Introduction.- 2. Melanomas.- 3. Discussion.- 4. Conclusions.- 5. Sarcomas.- 6. Results.- 7. Discussion.- 8. Conclusions.
Series Title: Recent results in cancer research, 59.
Responsibility: edited by A. Rossi-Fanelli [and others].

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