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Sequence alignment : methods, models, concepts, and strategies

Author: Michael S Rosenberg
Publisher: Berkeley : University of California Press, ©2009.
Edition/Format:   Print book : State or province government publication : EnglishView all editions and formats
Summary:
"The sequencing of the human genome involved thousands of scientists but used relatively few tools. Today, obtaining sequences is simpler, but aligning the sequences - making sure that sequences from one source are properly compared to those from other sources - remains a complicated but underappreciated aspects of comparative molecular biology. This volume is about the practice of alignment, the procedures by which  Read more...
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Material Type: Government publication, State or province government publication, Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Michael S Rosenberg
ISBN: 9780520256972 0520256972
OCLC Number: 233261197
Description: xvi, 337 pages : illustrations ; 24 cm
Contents: Sequence alignment : concepts and history --
Insertion and deletion events, their molecular mechanisms, and their impact on sequence alignments --
Local versus global alignments --
Computing multiple sequence alignment with template-based methods --
Sequence evolution models for simultaneous alignment and phylogeny reconstruction --
Phylogenetic hypotheses and the utility of multiple sequence alignment --
Structural and evolutionary considerations for multiple sequence alignment of RNA, and the challenges for algorithms that ignore them --
Constructing alignment benchmarks --
Simulation approaches to evaluating alignment error and methods for comparing alternate alignments --
Robust inferences from ambiguous alignments --
Strategies for efficient exploitation of the informational content of protein multiple alignments.
Responsibility: edited by Michael S. Rosenberg.
More information:

Abstract:

The sequencing of the human genome involved thousands of scientists but used relatively few tools. This book covers molecular causes, computational advances, approaches for assessing alignment  Read more...

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