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Signaling pathways in liver diseases

Author: Jean-François Dufour, (Professor of hepatology); Pierre-Alain Clavien
Publisher: Berlin ; New York : Springer, ©2005.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
"Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Signaling pathways in liver diseases.
Berlin ; New York : Springer, ©2005
(DLC) 2004111359
(OCoLC)60375131
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Jean-François Dufour, (Professor of hepatology); Pierre-Alain Clavien
ISBN: 9783540271949 3540271945 9783540229346 3540229345 9786611329655 661132965X
OCLC Number: 209861324
Description: 1 online resource (xv, 442 pages) : illustrations
Contents: Hepatocytes --
Signaling pathways in biliary epithelial cells --
Stellate cells --
Kupffer cells --
Hepatic sinusoidal endothelial cells --
Extracellular matrix --
IL-6/gpl30/Stat3 --
Vascular endothelial growth factor signaling --
Insulin pathway --
Nature and function of hepatic tumor necrosis factor-a signaling --
The Fas/FasL signaling pathway --
Tgf-B and the Smad pathway in liver fibrogenesis --
Interferon signaling --
CD14 and toll receptor --
The Wnt/B-Catenin pathway --
Notch signaling in liver disease --
Extracellular ATP: important developments in purinergic signaling --
Calcium signaling --
MAP kinase pathways in the control of hepatocyte growth, metabolism and survival --
PI3K, PTEN and Akt --
TOR signaling and cell growth control --
Peroxisome proliferator activated receptors --
Transcriptional response to cAMP in the liver --
Heme oxygenase system --
Nitric oxide --
Hypoxia-inducible factor-1 signaling system --
Cyclins and CDKs in liver diseases --
Telomeres and telomerase: distinctive roles in liver regeneration, cirrhosis and carcinogenesis --
NF-kB --
Ceramide: cell regulation from a lipid perspective --
Apoptosis and mitochondria --
Ubiquitin-proteasome pathway in the pathogenesis of liver disease --
Biological clock in the liver --
Pharmacogenomics of cholestatic liver disease --
Proteomics of signal transduction pathways.
Responsibility: Jean-François Dufour, Pierre-Alain Clavien, eds. ; co-editors, Christian Trautwein, Rolf Graf.

Abstract:

Die rasanten Fortschritte in der Leberforschung und die steigende Anzahl der operativen Eingriffe an der Leber verlangen vom praktizierenden Chirurgen das Verstandnis der molekularen Mechanismen ,  Read more...

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From the reviews: "The text extensively describes all the known intracellular pathways present in the liver and relevant to the pathophysiology of liver diseases. a ] The text has been well written Read more...

 
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