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Single nucleotide polymorphisms : methods and protocols

Author: Anton A Komar
Publisher: New York, NY : Humana Press, ©2009.
Series: Springer protocols (Series); Methods in molecular biology (Clifton, N.J.), v. 578.
Edition/Format:   eBook : Document : English : 2nd edView all editions and formats
Database:WorldCat
Summary:
In recent years, single nucleotide polymorphisms have received increased and special attention in a rapidly developing field of personalized medicine and drug treatment. Comprising more than eighty percent of all known polymorphisms, single nucleotide polymorphisms (SNPs) are primarily responsible for phenotypic differences between individuals, and have been suggested to affect the development of diseases in humans  Read more...
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Genre/Form: Laboratory Manuals
Electronic books
Laboratory manuals
Additional Physical Format: Print version:
Single nucleotide polymorphisms.
New York : Humana, 2009
(DLC) 2009933280
(OCoLC)429183476
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Anton A Komar
ISBN: 9781603274111 1603274111
OCLC Number: 439837807
Description: 1 online resource (xiv, 464 pages) : illustrations.
Contents: SNPs : impact on gene function and phenotype / B.S. Shastry --
Silent (synonymous) SNPs : should we care about them? / R. Hunt [and others] --
SNP databases / C. Phillips --
Mining SNPs from DNA sequence data : computational approaches to SNP discovery and analysis / J. van Oeveren and A. Janssen --
Next-generation sequencing methods : impact of sequencing accuracy on SNP discovery / E.Y. Chan --
Scanning probe and nanopore DNA sequencing : core techniques and possibilities / J. Lund and B.A. Parviz --
Pyrosequencing for SNP genotyping / J.L. Royo and J.J. Galan --
Single nucleotide polymorphism screening with denaturing gradient gel electrophoresis / L.A. Knapp --
Temporal temperature gradient electrophoresis for detection of single nucleotide polymorphisms / B.M. Jones and L.A. Knapp --
Zn(II)-cyclen polyacrylamide gel electrophoresis for SNP detection / E. Kinoshita-Kikuta, E. Kinoshita and T. Koike --
Phosphate-affinity polyacrylamide gel electrophoresis for SNP genotyping / E. Kinoshita, E. Kinoshita-Kikuta and T. Koike --
Estimation of SNP allele frequencies by SSCP analysis of pooled DNA / T. Tahira [and others] --
Phenylethynylpyrene excimer forming hybridization probes for fluorescence SNP detection / I.A. Prokhorenko [and others] --
The chemical cleavage of mismatch for the detection of mutations in long DNA fragments / T. Tabone, G. Sallmann and R.G. Cotton --
Mismatch oxidation assay : detection of DNA mutations using a standard UV/Vis microplate reader / T. Tabone, G. Sallmann and R.G. Cotton --
High-throughput methods for SNP genotyping / C. Ding and S. Jin --
High-throughput SNP genotyping : combining tag SNPs and molecular beacons / L.B. Barreiro, R. Henriques and M.M. Mhlanga --
SNP genotyping by the 5'-nuclease reaction : advances in high-throughput genotyping with nonmodel organisms / J.E. Seeb [and others] --
The TaqMan method for SNP genotyping / G.Q. Shen, K.G. Abdullah and Q.K. Wang --
Qualitative and quantitative genotyping using single base primer extension coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MassARRAY) / P. Oeth [and others] --
SNP detection using trityl mass tags / K.R. Birikh [and others] --
Putting the Invader assay to work : laboratory application and data management / Y. Zhang, E. Smith and M. Olivier --
SNP genotyping using multiplex single base primer extension assays / D. Podini and P.M. Vallone --
High-throughput SNP detection based on PCR amplification on magnetic nanoparticles using dual-color hybridization / N. He, S. Li and H. Liu --
Restriction enzyme analysis of PCR products / M. Ota [and others] --
Allele-specific PCR in SNP genotyping / M. Gaudet [and others] --
Modified multiple primer extension method / T. Yanagawa and H. Koga --
Detection of SNP by the isothermal smart amplification method / A. Lezhava and Y. Hayashizaki.
Series Title: Springer protocols (Series); Methods in molecular biology (Clifton, N.J.), v. 578.
Responsibility: edited by Anton A. Komar.
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Abstract:

In this updated second edition, researchers explore the latest advances in this area, highlighting the progress made in SNP genotyping, recent developments in high-throughput genotyping, and our new  Read more...

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From the reviews of the second edition: "This second edition brings 11 new chapters ... . Its target audience continues to be researchers and laboratory personnel. One helpful feature the book Read more...

 
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