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Site-directed insertion of transgenes

Author: Sylvaine Renault; Philippe Duchateau
Publisher: Dordrecht ; New York : Springer, ©2013.
Series: Topics in current genetics, 23.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
The post-genomic era has brought new challenges and opportunities in all fields of the biology. In this context, several genome engineering technologies have emerged that will help deciphering genes function by as well as improve gene therapy strategies. Genomic modifications such as knock-in, knock-out, knock-down, sequence replacement or modification can today be routinely performed. However, in front of this  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Sylvaine Renault; Philippe Duchateau
ISBN: 9789400745315 9400745311 9400745303 9789400745308
OCLC Number: 806230393
Description: 1 online resource.
Contents: Transgene Site-Specific Integration: Problems and Solutions / Solenne Bire and Florence Rouleux-Bonnin --
Designing Non-viral Targeted Integrating Vectors for Genome Engineering in Vertebrates / Ludivine Sinzelle and Nicolas Pollet --
Gene Targeting and Homologous Recombination in Saccharomyces cerevisiae / Judith Miné-Hattab and Rodney Rothstein --
Homologous Recombination in Mammals / Aurélia Barascu, Anastazja Grabarz and Bernard S. Lopez --
Engineered Zinc Finger Nucleases for Targeted Genome Editing / Cherie L. Ramirez and J. Keith Joung --
Engineered Meganucleases for Genome Engineering Purposes / Jean Charles Epinat, George H. Silva, Frédéric Pâques, Julianne Smith and Philippe Duchateau --
Cre/loxP, Flp/FRT Systems and Pluripotent Stem Cell Lines / Candice G. T. Tahimic, Kenji Sakurai, Kazuhiro Aiba and Norio Nakatsuji --
Site-Specific Recombination Using PhiC31 Integrase / Jonathan M. Geisinger and Michele P. Calos --
Modified Transposases for Site-Directed Insertion of Transgenes / Sean Colloms and Sylvaine Renault --
Targeted Plasmid Integration into the Human Genome by Engineered Recombinases / Charles A. Gersbach and Carlos F. Barbas III --
Gene Site-Specific Insertion in Plants / Olivier Da Ines and Charles I. White --
Site-Directed Insertion of Transgenes in Drosophila / Dana Carroll --
Nuclease Mediated Targeted Genome Modification in Mammalian Cells / Jenny C. Barker, Richard A. Voit and Matthew H. Porteus --
Bio-applications Derived from Site-Directed Genome Modification Technologies / Christophe Delenda, Sébastien Paris, Sylvain Arnould, Edward Balbirnie and Jean-Pierre Cabaniols.
Series Title: Topics in current genetics, 23.
Responsibility: Sylvaine Renault, Philippe Duchateau [editors].

Abstract:

This book surveys the field from mechanisms of site-directed modifications to application in organisms such as bacteria, yeast, plants, insects and mammals. Covers technologies based on Zinc Finger  Read more...

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