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Skin sensitization in chemical risk assessment.

Author: Hendrik van LoverenWorld Health Organization.International Program on Chemical Safety.International Labour Organisation.United Nations Environment Programme.All authors
Publisher: Geneva, Switzerland : World Health Organization, ©2008.
Series: Harmonization Project document, no. 5.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This publication presents the conclusions of an IPCS Workshop on Skin Sensitization in Chemical Risk Assessment. The workshop focused on the question of methods for dose-response assessment, to evaluate the relative ability of a chemical to induce sensitization in the skin, and hence inform risk assessment for humans. In addition this publication includes a series of short articles on this topic by leading experts  Read more...
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Genre/Form: Electronic books
Computer network resources
Additional Physical Format: Print version:
Skin sensitization in chemical risk assessment.
Geneva, Switzerland : World Health Organization, ©2008
(DLC) 2009388560
(OCoLC)264018235
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Hendrik van Loveren; World Health Organization.; International Program on Chemical Safety.; International Labour Organisation.; United Nations Environment Programme.; Inter-Organization Programme for the Sound Management of Chemicals.
OCLC Number: 567939881
Description: 1 online resource (iv, 85 pages) : illustrations.
Contents: Skin sensitization in chemical risk assessment : report of a WHO/IPCS international workshop focusing on dose-response assessment / H. Van Loveren [and others].
Series Title: Harmonization Project document, no. 5.

Abstract:

This publication presents the conclusions of an IPCS Workshop on Skin Sensitization in Chemical Risk Assessment. The workshop focused on the question of methods for dose-response assessment, to evaluate the relative ability of a chemical to induce sensitization in the skin, and hence inform risk assessment for humans. In addition this publication includes a series of short articles on this topic by leading experts in the field. The conclusions of the workshop cover such aspects as the nature and utility for risk assessment of the data produced by non-animal test methods (such as quantitative structure-activity relationships), in vitro testing approaches, animal test methods, and epidemiological studies. While traditional animal test methods used for identification and regulation of skin sensitizers have focused on determining whether or not a substance is a sensitizer, this report describes the use of tests for deriving more informative potency information.--Publisher's description.

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