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Solid-phase synthesis : a practical guide

Author: Steven A Kates; Fernando Albericio
Publisher: New York : Marcel Dekker, ©2000.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
"This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules."--Publisher  Read more...
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Genre/Form: Aufsatzsammlung
Document Type: Book
All Authors / Contributors: Steven A Kates; Fernando Albericio
ISBN: 0824703596 9780824703592
OCLC Number: 43569513
Description: xx, 826 pages : illustrations ; 24 cm
Contents: The solid support --
Strategy in solid-phase peptide synthesis --
Amino acids: alpha-amino protecting groups --
Side-chain protecting groups --
Solid supports for the synthesis of peptides and small molecules --
Coupling methods: solid-phase formation of amide and ester bonds --
Homodetic cyclic peptides --
Disulfide formation in synthetic peptides and proteins: the state of the art --
Solid-phase convergent approaches to the synthesis of native peptides and proteins --
Preparation of glyco-, phospho-, and sulfopeptides --
Oligonucleotide synthesis --
Synthesis of oligonucleotide-peptide conjugates and nucleopeptides --
The chemistry of peptide nucleic acids --
Solid-phase synthesis of oligosaccharides --
Solid-phase synthesis of heterocyclic compounds from amino acids and linear peptides --
Solid-phase synthesis of pseudopeptides and oligomeric peptide backbone mimetics --
Instrumentation --
The purification of synthetic peptides --
Analysis of synthetic peptides --
The chromatographic analysis of combinatorial arrays: parallel HPLC and HPLC-MS.
Responsibility: edited by Steven A. Kates, Fernando Albericio.
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Abstract:

Offers the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and  Read more...

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"Prepublication praise for Solid-Phase Synthesis. . . Both Fernando Albericio and Steven Kates, as well as most of the authors of individual chapters, are well known to members of the synthetic Read more...

 
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