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Specificity, Function, and Development of NK Cells : NK Cells: The Effector Arm of Innate Immunity

Author: Klas Kärre; Marco Colonna
Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 1998.
Series: Current topics in microbiology and immunology, 230.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Our understanding of the function of natural killer (NK) cells has dramatically changed in recent years. The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Klas Kärre; Marco Colonna
ISBN: 9783642468599 3642468594 9783540639411 3540639411
OCLC Number: 851840536
Description: 1 online resource (ix, 248 pages 22 illustrations).
Contents: A. NK Receptors and Coreceptors --
Regulation of Mouse NK Cells by Structurally Divergent Inhibitory Receptors --
Stimulatory Receptors in NK and T Cells --
Killer Cell Inhibitory Receptor Expression by T Cells --
The CD94/NKG2 C-Type Lectin Receptor Complex --
Triggering of Natural Killer Cell Mediated Cytotoxicity by Costimulatory Molecules --
Fc Receptors on Natural Killer Cells --
Adhesion in NK Cell Function --
B. Activation of NK Cells and Effector Functions --
Signal Transduction During NK Cell Activation: Balancing Opposing Forces --
Effector Pathways of Natural Killer Cells --
C. Development of NK Cells --
Toward a Quantitative Analysis of the Repertoire of Class I MHC-Specific Inhibitory Receptors on Natural Killer Cells --
Ontogeny and Differentiation of Murine Natural Killer Cells and Their Receptors --
D. Role of NK Cells in Infections and Tumors --
Control of Infections by NK Cells --
Natural Killer Cells and Tumor Therapy.
Series Title: Current topics in microbiology and immunology, 230.
Responsibility: edited by Klas Kärre, Marco Colonna.

Abstract:

The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and  Read more...

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