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Sphingolipids : basic science and drug development

Autor: Erich Gulbins; Irina Petrache
Editora: Vienna ; New York : Springer, ©2013.
Séries: Handbook of experimental pharmacology, v. 215.
Edição/Formato   e-book : Documento : InglêsVer todas as edições e formatos
Resumo:
Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of  Ler mais...
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Detalhes

Gênero/Forma: Electronic books
Formato Físico Adicional: Printed edition:
Tipo de Material: Documento, Recurso Internet
Tipo de Documento Recursos de internet, Arquivo de computador
Todos os Autores / Contribuintes: Erich Gulbins; Irina Petrache
ISBN: 9783709113684 3709113687
Número OCLC: 840600290
Notas: Includes index.
Descrição: 1 online resource.
Conteúdos: Part I Basic Mechanisms. The Genetics of Sphingolipid Hydrolases and Sphingolipid Storage Diseases / Edward H. Schuchman, Calogera M. Simonaro --
Sphingolipids and Membrane Domains: Recent Advances / Salvatore Chiantia, Erwin London --
Sphingolipid Metabolism and Neutral Sphingomyelinases / Michael V. Airola, Yusuf A. Hannun --
Acid Sphingomyelinase / Brian Henry [and others] --
Ceramide Synthases: Reexamining Longevity / Joo-Won Park, Yael Pewzner-Jung --
Membrane Channels Formed by Ceramide / Marco Colombini --
Genetic Disorders of Simple Sphingolipid Metabolism / Virginie Albinet [and others] --
The Role of Ceramide-1-Phosphate in Biological Functions / L. Alexis Hoeferlin, Dayanjan S. Wijesinghe, Charles E. Chalfant --
Part II Drug Development. Functional Inhibitors of Acid Sphingomyelinase (FIASMAs) / Johannes Kornhuber [and others] --
Novel Drugs Targeting Sphingolipid Metabolism / Krishna P. Bhabak, Christoph Arenz --
The Therapeutic Potential of Nanoscale Sphingolipid Technologies / Jody L. Hankins [and others] --
Novel Chemotherapeutic Drugs in Sphingolipid Cancer Research / Daniel Canals, Yusuf A. Hannun --
Pharmacology of the Sphingosine-1-Phosphate Signalling System / Dagmar Meyer zu Heringdorf, Katja Ihlefeld, Josef Pfeilschifter.
Título da Série: Handbook of experimental pharmacology, v. 215.
Responsabilidade: Erich Gulbins, Irina Petrache, editors.

Resumo:

This book examines the physiological and pathophysiological role of sphingolipids and their derivative ceramide, and their function in cell signalling, tumor metastasis, cardiovascular disease and  Ler mais...

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