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Src family tyrosine kinases in leukocytes

Author: Tomas Mustelin
Publisher: Austin : R.G. Landes, 1994.
Series: Molecular biology intelligence unit (Unnumbered)
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

This work is devoted to the biology of the src family of proto-oncogene products in leukocytes. This gene family encodes nonreceptor protein tyrosine kinases (PTKs) and consists of nine members, many  Read more...

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Additional Physical Format: Online version:
Mustelin, Tomas.
Src family tyrosine kinases in leukocytes.
Austin : R.G. Landes, 1994
(OCoLC)622121387
Document Type: Book
All Authors / Contributors: Tomas Mustelin
ISBN: 157059113X 9781570591136
OCLC Number: 30078906
Description: v, 155 pages : illustrations ; 27 cm.
Contents: On the leukocytes: a brief introduction --
Leukopoiesis --
Mature leukocytes --
Leukocyte surface receptors --
Src-like kinases: a family of ten --
Protein tyrosine kinases (PTKs) --
Discovery of the src gene family --
Genes of the src-family PTKs --
Overall structure of Src-like PTKs --
Introducing the family members --
Other PTKs in leukocytes --
Regulation of src-family PTKs --
Regulation of the type and amount of family members --
Regulation of translation --
Post-translational mechanisms --
Reversible phosphorylation at the C-terminus. Autophosphorylation --
Positive regulation by N-terminal tyrosine phosphorylation --
Serine/threonine phosphorylation of src-family PTKs --
Other covalent modifications --
Regulation via SH3 and SH2 domains --
Regulation by associated proteins --
Other mechanisms of regulation --
Role of src-family PTKs in leukocyte physiology --
Role of src-family PTKs in lymphocyte activation --
Reversion of lymphocyte proliferation --
Role of src-family PTKs in lymphocyte development and apoptosis --
Role of src-family PTKs in granulocyte and macrophage physiology. Src-family PTKs in mast cell activation --
src-family PTKs in platelet activation --
Src-like PTKs in cancer, viral infections and leukocyte disorders --
Substrates of src-family PTKs --
Substrate specificity of src-family PTKs --
Receptor subunits --
Enzymes involved in phospholipid metabolism --
Regulators of Ras and other small GTP-binding proteins --
Serine/threonine-specific protein kinases --
Other kinases and phosphatases as targets for src-family PTKs --
Glycolytic enzymes --
Cytoskeletal proteins --
Proteins of unknown function. Synopsis and future perspectives --
Regulation --
Physiological functions.
Series Title: Molecular biology intelligence unit (Unnumbered)
Responsibility: Tomas Mustelin.

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