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Statistical methods in drug combination studies

Author: Wei Zhao; Harry Yang
Publisher: Boca Raton : CRC Press, [2015] ©2015
Series: Chapman & Hall/CRC biostatistics series.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Drug combination research has become increasingly important as multi-drug treatments may overcome disease resistance to monotherapies given the heterogeneous nature of complex diseases, such as cancer. To screen for potential candidates, rigorous statistical methods must used to avoid a high proportion of false-positive recommendations, resulting in a tremendous waste of time and resources. This book covers all  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Zhao, Wei.
Statistical Methods in Drug Combination Studies.
Hoboken : Taylor and Francis, ©2015
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Wei Zhao; Harry Yang
ISBN: 9781482216752 1482216752
OCLC Number: 900602671
Description: 1 online resource.
Contents: Drug combination : much promise and many hurdles / Harry Yang and Laura Richman --
Drug combination synergy / Harry Yang, Steven J. Novick, and Wei Zhao --
Drug combination design strategies / Steven J. Novick and John J. Peterson --
Confidence interval for interaction index / Maiying Kong and J. Jack Lee --
Two-stage response surface approaches to modeling drug interaction / Wei Zhao and Harry Yang --
A Bayesian industry approach to phase I combination trials in oncology / Beat Neuenschwander [and five others] --
Statistical methodology for evaluation combination therapy in clinical trials / H.M. James Hung, Sue-Jane Wang --
Challenges and opportunities in analysis of drug combination clinical trial data / Yaning Wang, Hao Zhu, Liang Zhao, and Ping Ji --
Statistical computational tools for ADA analysis / Cheng Su.
Series Title: Chapman & Hall/CRC biostatistics series.
Responsibility: edited by Wei Zhao, MedImmune, LLC, Gaithersburg, Maryland, USA; Harry Yang, MedImmune, LLC, Gaithersburg, Maryland, USA.

Abstract:

Drug combination research has become increasingly important as multi-drug treatments may overcome disease resistance to monotherapies given the heterogeneous nature of complex diseases, such as cancer. To screen for potential candidates, rigorous statistical methods must used to avoid a high proportion of false-positive recommendations, resulting in a tremendous waste of time and resources. This book covers all statistical aspects of drug combination research, from designing in vitro drug combination studies to analyzing clinical trial data.

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