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Stearoyl-CoA Desaturase Genes in Lipid Metabolism

Author: Ph D James M Ntambi
Publisher: New York, NY : Springer New York : Imprint: Springer, 2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
James Ntambi has gathered top authors to write about the remarkable growth of research on the role of the stearoyl-CoA desaturase (SCD) genes in metabolism in different species including human. The book shows that beginning with simple cellular models of differentiation a broad and comprehensive analysis of the SCD gene family in a number of species and biological systems has been carried out over the course of the  Read more...
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Details

Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ph D James M Ntambi
ISBN: 9781461479697 146147969X
OCLC Number: 890437422
Description: 1 online resource (XI, 239 p. 42 illus., 24 illus. in color.) online resource.
Contents: SCD genes of fatty acid synthesis --
SCD genes in heart metabolism --
SCD genes in liver metabolism --
SCD genes in harderian and perpetual glands --
SCD genes In lipogenesis --
SCD genes lipoproteins --
SCD genes in WAT --
SCD genes in muscle --
SCD genes in the brain --
SCD genes in inflammation --
SCD genes in ER Stress --
SCD genes in skin --
SCD genes in insulin signaling --
SCD genes in thermogenesis --
SCD genes in diabetes --
SCD genes atherosclerosis --
SCD genes in Adipocyte differentiation --
SCD genes and epigenetics --
SCD genes in fatty liver disease --
SCD genes in Colitis --
SCD genes in leptin signaling.
Responsibility: edited by James M. Ntambi, Ph.D.

Abstract:

James Ntambi has gathered top authors to write about the remarkable growth of research on the role of the stearoyl-CoA desaturase (SCD) genes in metabolism in different species including human. The book shows that beginning with simple cellular models of differentiation a broad and comprehensive analysis of the SCD gene family in a number of species and biological systems has been carried out over the course of the last twenty five years. SCD is a central enzyme in lipid metabolism that synthesizes monounsaturated fatty acids (MUFA) from saturated fatty acid precursors. At first glance, SCD would be considered a housekeeping enzyme because its product oleate is a well-known MUFA that is abundant in many dietary sources and tissue lipids. A particular highlight in the chapters of the book is that MUFAs may have signaling properties that regulate metabolism. For example, a proper ratio of saturated to MUFA contributes to membrane fluidity, and oleate has also been implicated as a mediator of signal transduction, cellular differentiation and metabolic homeostasis. It is also highlighted that SCD-1 repression mediates the metabolic effects of the hormone leptin. Conditional alleles and corresponding tissue-specific knockout mouse models for many of the SCD gene isorfms have provided a wealth of information on not only tissue-specific fatty acid metabolism but also the key transcription factors that regulate SCD expression under a variety of metabolic and genetic backgrounds. The studies described indicate that control of SCD expression occurs via a series of complex signal transduction schemes making SCD one of the most highly studied lipogenic gene families to date.

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