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  E-mail Message: I thought you might be interested in this item at http://www.worldcat.org/oclc/117658192 Title: Stellate cell inhibition of Purkinje cells in the turtle cerebellum in vitro. Publisher: ISBN/ISSN: 0022-3751 OCLC:117658192

  
  

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Stellate cell inhibition of Purkinje cells in the turtle cerebellum in vitro.

Author:	J Midtgaard
Edition/Format:	Article : English
Publication:	The Journal of physiology, 1992 Nov; 457: 355-67
Database:	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Summary:	1. The stellate cell-mediated inhibition of Purkinje cells was studied by intracellular recordings in an in vitro slice preparation of the turtle cerebellar cortex. A graded inhibitory postsynaptic potential (IPSP) was recorded in Purkinje cells upon stimulation of the parallel fibre-stellate cell pathway. 2. The IPSP was abolished by bicuculline, and had a reversal potential around -75 mV, consistent with a GABAA receptor-operated Cl- conductance dominating the response investigated here. 3. Paired recordings from synaptically coupled stellate cells and Purkinje cells demonstrated that the inhibitory input from a single stellate cell is sufficient to reduce the firing in a Purkinje cell. 4. The extracellular-evoked IPSP interacted with the active postsynaptic membrane properties in the Purkinje cell. Interaction with both the Na+ plateau and the IA prolonged the responses to an IPSP, making the net effect of the inhibitory response dependent on the membrane potential in each postsynaptic neurone. 5. A precisely timed IPSP was particularly efficient in reducing dendritic Ca2+ influx. 6. The voltage-dependent Ca2+ component of a climbing fibre response (CFR) as well as of a parallel fibre (PF) input was reduced by the IPSP. 7. It is suggested that Ca2+ spike-mediated reduction in Purkinje cell excitability may be prevented by the stellate cell IPSP-mediated reduction in Ca2+ influx.  Read more...
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