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Stem cells and extracellular matrices

Author: Lakshmi Kiran Chelluri
Publisher: San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, ©2012.
Series: Colloquium digital library of life sciences.; Colloquium series on stem cell biology, # 1.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Stem cells have great potential in regenerative medicine and tissue injury. Regulation of stem cell homeostasis in a 3D microenvironment is controlled by the niche components that influence stem cell fate, regulation, and function. It is therefore necessary to understand the mechanisms of cell-cell interaction, molecular cross talk between stem cells and their extracellular matrix (ECM) environment. The adhesion  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Chelluri, Lakshmi Kiran.
Stem cells and extracellular matrices.
San Rafael, CA : Morgan & Claypool, ©2012
(OCoLC)791643261
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Lakshmi Kiran Chelluri
ISBN: 9781615043774 1615043772 1615043764 9781615043767
OCLC Number: 787601703
Description: 1 online resource (ix, 74 pages) : illustrations.
Contents: 1. Introduction to stem cell biology and niche components --
1.1 Basic stem cell biology --
1.1.1 Types of stem cells --
1.1.2 Stem cells and differentiation --
1.2 The living environment of stem cells, extracellular matrix (ECM) --
1.2.1 Soluble factors --
1.2.2 Cell-cell interaction --
1.2.3 Extracellular matrix proteins --
1.2.4 Forces --
2. ECM, structure and organization --
2.1 Constituents of ECM --
2.1.1 Collagen, a structural protein of ECM --
2.1.2 Elastin fibers --
2.1.3 Proteoglycans and gags in the ECM --
2.1.4 Hyaluronan --
2.1.5 Adhesive glycoproteins --
2.1.6 Basement membrane extract and specialized proteins --
2.1.7 Silk --
2.1.8 Design strategies for cell matrix engineering --
2.2 Biomechanical attributes of an ECM --
2.3 Matrix reactions and interactions --
2.4 Matrix designing for 3 dimensional stem cell cultures --
3. ECM control, regulation on stem cell fate and function --
3.1 Stem cell fate regulators --
3.1.1 ECM as a regulator of stem cell fate --
3.2 Stem cell topography in regulation of the ECM --
3.3 Signal transduction mechanisms in stem cell fate --
3.4 Control of ECM in stem cell-based tissue engineering --
4. ECM and stem cell cultures --
4.1 Embryonic stem cell cultures in natural ECM --
4.2 Embryonic stem cell cultures in synthetic ECM --
4.3 Hematopoietic stem cells in natural and synthetic ECM --
4.4 Undifferentiated and differentiated MSCs in ECM --
4.4.1 MSCs to osteogenic differentiation in ECM --
4.4.2 Chondrogenic differentiation of mscs in ECM --
4.4.3 Neural stem cells in ECM --
4.4.4 Endothelial progenitor cells in ECM --
4.4.5 Adipose-tissue-derived stem cells in ECM --
4.5 Challenges of stem cells in ECM --
4.6 Conclusion.
Series Title: Colloquium digital library of life sciences.; Colloquium series on stem cell biology, # 1.
Responsibility: Lakshmi Kiran Chelluri.
More information:

Abstract:

Stem cells have great potential in regenerative medicine and tissue injury. Regulation of stem cell homeostasis in a 3D microenvironment is controlled by the niche components that influence stem cell fate, regulation, and function. It is therefore necessary to understand the mechanisms of cell-cell interaction, molecular cross talk between stem cells and their extracellular matrix (ECM) environment. The adhesion molecules play a pivotal role in establishing the cell-cell contact and subsequent integration with the ECM. This understanding is the basis for establishing design criteria for biomimetic. The integrated approach by biologists, material science engineers, biomedical engineers, and clinicians is the key in the development of tissue engineered constructs for effective translation to clinics.

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