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Stem cells : scientific facts and fiction

Author: C L Mummery; Anja van de Stolpe; Bernard A J Roelen; Hans Clevers
Publisher: London : Elsevier/AP, Academic Press is an imprint of Elsevier, 2014.
Edition/Format:   Print book : English : Second editionView all editions and formats
Database:WorldCat
Summary:
"The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major  Read more...
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Document Type: Book
All Authors / Contributors: C L Mummery; Anja van de Stolpe; Bernard A J Roelen; Hans Clevers
ISBN: 9780124115514 0124115519
OCLC Number: 879582378
Description: xi, 433 pages : illustrations (chiefly color), color map, portraits ; 23 cm
Contents: 1. The biology of the cell --
Organisms' composition --
Deoxyribonucleic acid , genes, and chromosomes --
How the amount of messenger ribonucleic acid is regulated --
From messenger ribonucleic acid to a functional protein --
From deoxyribonucleic acid and proteins to a cell with a specific function --
Deoxyribonucleic acid differences between genomes --
Disease due to variations and genome mutations --
Dominant or recessive --
Deoxyribonucleic acid outside the nucleus : bacterial remains --
Cell lines and cell culture --
2. Embryonic development --
Fertilization and early embryo development --
Sex cells and germ cell tumors --
3. What are stem cells? --
What are the properties of stem cells that make them different from other cells? --
Totipotency and pluripotency, and embryonic stem cells --
Multipotency, unipotency, and adult stem cells --
Cell division and aging : the role of telomerase --
The relationship between cell division and differentiation : epigenetics --
Epigenetics in stem cells --
4. Of mice and men : the history of embryonic stem cells --
How it all began : pluripotent cells in early embryos --
Mouse embryonal carcinoma cell lines --
Pluripotent cells in an early embryo --
Mouse embryonic stem cell lines --
Toward human embryonic stem cells --
On the road to stem cell therapy --
Biased interpretation --
The future : stem cell transplantation as clinical treatment --
Breakthrough of the decade in the twenty-first century : induced pluripotent stem cells --
5. Origins and types of stem cells : what's in a name? --
Pluripotent stem cells --
Multipotent stem cells --
6. Cloning : history and current applications --
Before Dolly --
Cloning pets : Snuppy, Missy, and Copycat --
Just imagine what could be --
Cloning domestic livestock --
Cloning challenges --
7. Regenerative medicine : clinical applications of stem cells --
Therapeutic cell transplantation --
Number of cells needed for cell transplantation --
Why some disease will be treatable with stem cells in the future and others not --
The best stem cells for transplantation --
Combining gene therapy with stem cell transplantation --
Where to transplant stem bells and their effect --
Cell types available for cell transplantation --
Transplantation of stem bells : where we stand --
Risks associated with a stem cell transplantation --
Stem cells rejected after transplantation --
Tissue engineering --
8. Stem cells in veterinary medicine --
Treatment of family pets --
9. Cardiomyocytes from stem cells : what can we do with them? --
The heart and cardiac repair --
From pluripotent stem cells to cardiomyocytes --
10. Adult stem cells : generation of self-organizing mini-organs in a dish --
Adult stem cells in internal organs --
Adult stem cells in the intestine --
Adult stem cells in muscle tissue --
What we have learnt about adult stem cells --
The future : organoids to repair tissues and organs --
11. Stem cell tourism --
Definition of stem cell tourism --
What's the difference between trials and treatment? --
Perspective of the International Society for Stem Cell Research --
12. Cancer stem cells : where do they come from and where are they going? --
Cancer : observations and questions --
Introduction to stem cells and cancer --
The behavior off cancer cells : not all tumors and not all cells within a tumor look the same --
Colon adenoma : a case in point for th role of an adult stem cell as the stem cell of origin --
How to become a cancer stem cell : epithelial mesenchymal transition --
How developmental signal transduction pathways become active in cancer cells --
Cancer stem cells as circulating tumor cells --
The final step : initiation of metastatic growth --
A cancer stem cell : can it differentiate to another cell type? --
Cancer stem cells : development of new drugs to treat cancer --
Conclusions and research challenges --
13. Human stem cells for organs-on-chips : clinical trials without patients? --
Introduction --
Organs-on-chips --
Why we need human organ and disease-on-chip models --
Human organ-on-a-chip models for certain diseases --
Human disease models as organs-on-chips : challenges --
Where we are now with organ-on-a-chip technology --
Applications of organs-on-chips --
Conclusion --
14. Stem cells for discovery of effective and safe new drugs --
Drug discovery : a short historical perspective --
Modern drug discovery --
Challenges and opportunities in drug discovery --
How the safety of new drugs is secured --
15. Patents, opportunities, and challenges : legal and intellectual property issues associated with stem cells --
Companies and alliances --
Patent issues : current intellectual property landscape --
Europe versus the Unite States --
More legal and ethical issues --
16. Stem cell perspectives : a vision of the future --
Combining technologies : new human disease models for drug discovery --
Personalized medicine and safer drugs.
Other Titles: Stem cells (Mummery)
Responsibility: edited by Christine Mummery, Anja Van De Stolpe, Bernard A.J. Roelen, Hans Clevers.

Abstract:

"The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on "organs on chips" and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies."--Publisher information.

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"... an impressive encyclopedia of modern biotechnology that presents complex material in short, easy-to-grasp chapters...a solid, informative effort...Summing Up: Highly recommended."--CHOICE Read more...

 
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