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Stereochemical aspects of drug action and disposition

Author: S K Branch; Michel Eichelbaum; Bernard Testa; Andrew Somogyi
Publisher: Berlin ; New York : Springer, ©2003.
Series: Handbook of experimental pharmacology, v. 153.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This book aims to guide and inspire drug researchers as they enter the 21st century. Stereochemistry is an essential dimension in pharmacology and should be understood as such by all drug researchers whatever their background. When used as probes or medicines, stereoisomeric drugs offer invaluable insights or innovative therapeutic strategies. The book spans the subject from the molecular to the clinical. The first  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Stereochemical aspects of drug action and disposition.
Berlin ; New York : Springer, ©2003
(OCoLC)52515592
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: S K Branch; Michel Eichelbaum; Bernard Testa; Andrew Somogyi
ISBN: 9783642558429 3642558429
OCLC Number: 605971406
Reproduction Notes: Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL
Description: 1 online resource (xxv, 442 pages) : illustrations.
Details: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Contents: Ch. 1. Recent developments in asymmetric organic synthesis: principles and examples / P. Vogel --
Ch. 2. Stereoselective separations: recent advances in capillary electrophoresis and high-performance liquid chromatography / S. Rudaz and J.-L. Veuthey --
Ch. 3. Stereochemical issues in bioactive natural products / C. Terreaux and K. Hostettmann --
Ch. 4. Drug racemization and its significance in pharmaceutical research / M. Reist, B. Testa, and P.A. Carrupt --
Ch. 5. Physical properties and crystal structures of chiral drugs / C.-H. Gu and D.J.W. Grant --
Ch. 6. Chiral recognition in biochemical pharmacology: an overview / B. Testa and J.M. Mayer --
Ch. 7. Enantioselectivity in drug-receptor interactions / W. Soudun, I. van Wijngaarden, and A.P. Ijzerman --
Ch. 8. Mechanisms of stereoselective binding to functional proteins / G. Klebe --
Ch. 9. Stereoselective drug-channel interactions / C. Valenzuela --
Ch. 10. Stereoselective bioactivation and bioinactivation: toxicological aspects / N.P.E. Vermeulen --
Ch. 11. Intestinal drug transport: stereochemical aspects / H. Spahn-Langguth, C. Dressler, and C. Leisen --
Ch. 12. Enantioselective plasma and tissue binding / P.J. Hayball and D. Mauleón --
Ch. 13. Stereoselective drug metabolism and drug interactions / A.S. Gross, A. Somogyi, and M. Eichelbaum --
Ch. 14. Metabolic chiral inversion of 2-arylpropionic acids / L. Tegeder, K. Williams, and G. Geisslinger --
Ch. 15. Stereoselective renal elimination / C.M. Brett, R.J. Ott, and K.M. Giacomini --
Ch. 16. Regulatory requirements for the development of chirally active drugs / R.R. Shah and S.K. Branch --
Ch. 17. Improving clinical risk/benefit through stereochemistry / R.R. Shah.
Series Title: Handbook of experimental pharmacology, v. 153.
Responsibility: contributors, S.K. Branch [and others] ; editors, Michel Eichelbaum, Bernard Testa, and Andrew Somogyi.

Abstract:

This book aims to guide and inspire drug researchers as they enter the 21st century. Stereochemistry is an essential dimension in pharmacology and should be understood as such by all drug researchers whatever their background. When used as probes or medicines, stereoisomeric drugs offer invaluable insights or innovative therapeutic strategies. The book spans the subject from the molecular to the clinical. The first section on chemical aspects contains chapters on chemical synthesis, analysis, natural products, chiral stability (racemezation) and physical properties. The second section is on experimental pharmacology, with chapters on drug-receptor interactions, chiral recognition, ion channels, and molecular toxicology. The third section focuses on drug disposition, with chapters on absorption, distribution, protein binding, metabolism and elimination. The final section is dedicated to regulatory and clinical aspects.

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