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Steroid-Cell Interactions.

Author: R J B King; W I P Mainwaring
Publisher: Burlington : Elsevier Science, 2014.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Steroid-Cell Interactions describes the processes involved in the intracellular binding of steroids (and related compounds) in mammalian cells. Serum binding proteins and steroid-immunoglobulin interaction are also discussed, along with the relationship of these binding processes to the biological action of the steroid. This book consists of 10 chapters and begins by presenting an elementary account of the factors  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
King, R.J.B.
Steroid-Cell Interactions.
Burlington : Elsevier Science, ©2014
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: R J B King; W I P Mainwaring
ISBN: 9781483165103 1483165108
OCLC Number: 897651329
Description: 1 online resource (459 pages)
Contents: Front Cover; Steroid --
Cell Interactions; Copyright Page; Preface; Table of Contents; Introduction; Chapter 1. Physico-Chemical Considerations of Steroid-Receptor Interactions; STEROID STRUCTURE; PROTEIN STRUCTURE; NUCLEIC ACIDS; CHEMICAL BONDS; EQUILIBRIUM CONSTANT AND FREE ENERGY; REFERENCES; Chapter 2. Methods Used to Study Steroid-Tissue Receptor Interaction; CELL FRACTIONATION; CELL TYPE; AUTORADIOGRAPHY; DISTINCTION BETWEEN HIGH AND LOW AFFINITY BINDING SITES; REFERENCES; Chapter 3. The Importance of the Metabolism of Steroid Hormones Relative to their Binding and Mechanism of Action. THE ABSENCE OF THE METABOLISM OF STEROID HORMONES DURING THEIR UPTAKE AND RETENTION IN MANY TARGET CELLSTHE METABOLISM OF TESTOSTERONE IN ANDROGEN-DEPENDENT TISSUES; THE METABOLISM OF PROGESTERONE IN CERTAIN TARGET TISSUE; REFERENCES; Chapter 4. Androgens and particularly, a Metabolite of Testosterone, 5a-Dihydrotestosterone ; BLOOD; THE DISTRIBUTION OF NADPH-DEPENDENT 5a-REDUCTASE AND RECEPTORS FOR 5a-DIHYDROTESTOSTERONE IN ANDROGEN-SENSITIVE TISSUES AND CELLS; THE UPTAKE OF TESTOSTERONE INTO ANDROGEN-SENSITIVE ANDANDROGEN-DEPENDENT TISSUES. THE SPECIFIC, HIGH AFFINITY BINDING OF 5a-DIHYDR0-TESTOSTERONE IN THE RAT VENTRAL PROSTATE GLANDBINDING OF 5a-DIHYDROTESTOSTERONE IN ACCESSORY SEXUAL GLANDS OTHER THAN RAT VENTRAL PROSTATE GLAND; SEARCHES FOR RECEPTORS IN OTHER ANDROGEN-SENSITIVE SYSTEMS; BINDING OF ANDROGENS IN OTHER TISSUES AND CELLS; GENERAL SUMMARY; REFERENCES; Chapter 5. Glucocorticoids; BLOOD; SPECIFIC GLUCOCORTICOID RECEPTOR PROTEINS; LIVER; HTC CELLS; HeLa CELLS; LYMPHOCYTES; LYMPHOID TUMOURS; FIBROBLASTS; OTHER TISSUES; GENERAL SUMMARY; REFERENCES; Chapter 6. Mineralocorticoids; BLOOD. THE SEARCH FOR SPECIFIC ALDOSTERONE-BINDING PROTEINSRAT KIDNEY; TOAD BLADDER; OTHER TISSUES; GENERAL SUMMARY; REFERENCES; Chapter 7. Oestrogens; BLOOD; ENTRY OF OESTROGEN INTO CELLS; UTERUS; VAGINA; PITUITARY GLAND; BRAIN; OVARY; KIDNEY; PROSTATE AND SEMINAL VESICLE; OVIDUCT; MAMMARY GLAND; TUMOURS; OTHER TISSUES; REFERENCES; Chapter 8. Progesterone; BLOOD; OVIDUCT; UTERUS; OTHER TISSUES; REFERENCES; Chapter 9. Relationship of Binding to Biological Activity; INTRODUCTION; EVIDENCE THAT THE STEROID-RECEPTOR INTERACTION IS RELATED TO THE BIOLOGICAL ACTIVITY OF THE STEROID. PHYSIOLOGICAL ASPECTS OF STEROID-RECEPTOR INTERACTIONTHE MOLECULAR ASPECTS OF STEROID-RECEPTOR INTERACTION; REFERENCES; Chapter 10. Clinical and Immunological Aspects of Steroid-Binding; TERMINOLOGY; PLASMA PROTEINS; TISSUE PROTEINS; STEROID ANTIBODIES; REFERENCES; Appendix 1. Chemical and Trivial Names of Steroids; Appendix 2. Structure of synthetic Compound; Appendix 3. An Up-to-Date Summary of Current Literature; Index.

Abstract:

Steroid-Cell Interactions describes the processes involved in the intracellular binding of steroids (and related compounds) in mammalian cells. Serum binding proteins and steroid-immunoglobulin interaction are also discussed, along with the relationship of these binding processes to the biological action of the steroid. This book consists of 10 chapters and begins by presenting an elementary account of the factors contributing to the interaction between a steroid hormone and another molecule. The discussion then turns to the three types of methods used to study the interaction between steroids.

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