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Stroke : pathophysiology and therapy

Author: Jens Minnerup; Antje Schmidt; Christiane Albert-Weissenberger; Christoph Kleinschnitz
Publisher: San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, 2013.
Series: Colloquium digital library of life sciences.; Colloquium series on integrated systems physiology, # 42.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Stroke is a major global health problem because of its large contribution to mortality, morbidity, and disability. The most common form of stroke is ischemic stroke which accounts for approximately 80% of all strokes. During the past decade, our knowledge of the molecular and cellular processes that contribute to stroke pathophysiology has increased substantially and offers many targets for future therapeutic  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Jens Minnerup; Antje Schmidt; Christiane Albert-Weissenberger; Christoph Kleinschnitz
ISBN: 9781615045877 1615045872 1615045864 9781615045860
OCLC Number: 858674776
Notes: Part of: Colloquium digital library of life sciences.
Title from PDF title page (viewed on September 20, 2013).
Series from website.
Description: 1 online resource (1 PDF (viii, 91 pages)) : illustrations.
Contents: 1. Introduction --
1.1 Stroke classifications --
1.2 Epidemiology --
1.3 Acute therapy --
1.4 Prevention. 2. Pathophysiology of acute injury --
2.1 Excitotoxicity --
2.2 Oxidative stress --
2.2.1 Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are important generators of ROS --
2.2.2 Translational aspects --
2.3 Inflammatory cascades --
2.3.1 Detrimental effects of immune cell infiltration on ischemic brain injury --
2.3.2 Beneficial effects of immune cell infiltration on ischemic brain injury --
2.3.3 Translational aspects --
2.4 Thrombus formation --
2.4.1 Thrombus formation and its interrelationship with inflammation --
2.4.2 The coagulation cascade as a novel target in stroke therapy --
2.4.3 Inhibition of platelet function as a novel treatment strategy for stroke --
2.5 Cerebral edema formation --
2.5.1 Impact of aquaporin-4 (AQP4) on brain edema formation in ischemic brain injury --
2.5.2 The impact of the KKS on brain edema formation in ischemic brain injury. 3. Recovery and regeneration --
3.1 Neurological impairment after stroke and spontaneous recovery --
3.2 Neurogenesis --
3.3 Angiogenesis and vasculogenesis --
3.4 Axonal sprouting and dendritic plasticity. 4. Future therapeutic strategies --
4.1 Neuroprotection --
4.1.1 Introduction --
4.1.2 Translational failures of candidate neuroprotectants --
4.1.3 Ongoing studies on neuroprotective drugs for ischemic stroke --
4.1.4 Uric acid --
4.1.5 Magnesium --
4.1.6 Dapsone --
4.1.7 Albumin --
4.1.8 Ciclosporine --
4.1.9 THR-18 --
4.1.10 PF-03049423 --
4.1.11 Combining neuroprotection with thrombolysis --
4.1.12 Neuroprotection and hypothermia --
4.1.13 Conclusions --
4.2 Neurorestorative therapies --
4.2.1 Mechanisms of spontaneous recovery as basis for future treatments --
4.2.2 Growth factor treatment to enhance recovery after stroke --
4.2.3 Counteracting inhibition of axonal sprouting --
4.2.4 Cell therapy for stroke --
4.3 Approaches to improve translation. References.
Series Title: Colloquium digital library of life sciences.; Colloquium series on integrated systems physiology, # 42.
Responsibility: Jens Minnerup and Antje Schmidt, Christiane Albert-Weissenberger and Christoph Kleinschnitz.

Abstract:

Stroke is a major global health problem because of its large contribution to mortality, morbidity, and disability. The most common form of stroke is ischemic stroke which accounts for approximately 80% of all strokes. During the past decade, our knowledge of the molecular and cellular processes that contribute to stroke pathophysiology has increased substantially and offers many targets for future therapeutic strategies. This book provides an overview of the current knowledge of stroke pathophysiology and the mechanisms that interfere with recovery and regeneration. Moreover, this book reviews the latest advances in the development of future therapeutic strategies.

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