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Structural biology in immunology : structure/function of novel molecules of immunologic importance

Author: Chaim Putterman; David Cowburn; Steven Almo
Publisher: London, United Kingdom : Academic Press, an imprint of Elsevier, [2018] ©2018
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus,  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Structural biology in immunology.
London, United Kingdom : Academic Press, an imprint of Elsevier, [2018]
(OCoLC)992433771
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Chaim Putterman; David Cowburn; Steven Almo
ISBN: 9780128033708 0128033703
OCLC Number: 1035844945
Description: 1 online resource
Contents: Front Cover; Structural Biology in Immunology: Structure/Function of Novel Molecules of Immunologic Importance; Copyright; Contents; Contributors; Chapter 1: Organization of Immunological Synapses and Kinapses; 1.1 Introduction; 1.2 Receptors and Ligands of the Immunological Synapse and Kinapse; 1.2.1 T-cell Receptor and pAgMHC; 1.2.2 Adhesion Molecules; 1.2.3 Costimulatory and Checkpoint Receptors; 1.2.4 Nectins and Other Adhesion Receptors; 1.2.5 Coreceptors and Large Transmembrane Phosphatases; 1.3 Phase-Like Behavior and Phase Separation in Signaling. 1.3.1 Phase Separation in Adhesion Plane of Cell-Cell Interfaces1.3.2 Phase-Separated Lipid Domains in Plasma Membrane; 1.3.3 Phase Separation in Membrane Proximal Signaling; 1.3.4 Cytoskeletal Networks; 1.4 Microvilli/Filopodia; 1.4.1 Rosette-Shaped Actin Network; 1.5 Synaptic Cleft Formation; 1.5.1 Membrane Traffic to Maintain Signaling; 1.5.2 Extracellular Vesicles to Terminate Signaling and Relay Messages; 1.5.3 Directed Release of Effector Molecules Through Exocytosis; 1.6 Conclusions; Acknowledgments; References. Chapter 2: Principles of Protein Recognition by Small T-Cell Adhesion Proteins and Costimulatory Receptors2.1 Introduction; 2.2 Cell-Cell Recognition and Adhesion: CD2 Family Proteins; 2.2.1 Rat sCD2 (1992); 2.2.1.1 The Structure; 2.2.1.2 What We Learnt; 2.2.2 Human sCD2 (1994); 2.2.2.1 The Structure; 2.2.2.2 What We Learnt; 2.2.3 The Role of Charged Residues in Ligand Binding by CD2 (1998); 2.2.3.1 Mutational Analysis of Rat CD2; 2.2.3.2 What We Learnt; 2.2.4 CD58 d1 (1999); 2.2.4.1 The Structure; 2.2.4.2 What We Learnt; 2.2.5 CD48 d1 (2006); 2.2.5.1 The Structure; 2.2.5.2 What We Learnt. 2.3 Cell-Cell Recognition and Costimulation: CD28 Family Proteins2.3.1 sB7-1 (2000); 2.3.1.1 The Structure; 2.3.1.2 What We Learnt; 2.3.2 sCTLA-4/sB7-1 Complex (2001); 2.3.2.1 The Structure; 2.3.2.2 What We Learnt; 2.3.3 sCD28/5.11A1 Antibody Fab (2005); 2.3.3.1 The Structure; 2.3.3.2 What We Learnt; 2.3.4 sCTLA-4 (2011); 2.3.4.1 The Structure; 2.3.4.2 What We Learnt; 2.3.5 sPD-1 (2013); 2.3.5.1 The Structure and Interactions; 2.3.5.2 What We Learnt; 2.4 Concluding Remarks; Acknowledgments; References; Chapter 3: Synthetic Antibody Engineering: Concepts and Applications; 3.1 Introduction. 3.2 Immunoglobulin Structure and Function3.3 Engineering Phage-Displayed Antibody Libraries; 3.4 Applications; 3.4.1 Engineering of Conformation-Specific Antibodies; 3.4.2 Engineering of Cross-Reactive Antibodies; 3.4.3 Engineering of Antibodies Specific for Point-Mutants and PTMs; 3.5 Conclusions; References; Chapter 4: Natural Killer Cell Receptors; 4.1 Introduction; 4.2 MHC-I Recognition by Ly49 Receptors; 4.3 Ly49 Receptors Interact With MHC-I in Trans and Cis; 4.4 Ly49A's Recognition of a Viral Immunoevasin; 4.5 Recognition of MHC-I by KIR Receptors; 4.6 Recognition of MHC-I by LILRs.
Responsibility: edited by Chaim Putterman, David Cowburn, Steven Almo.

Abstract:

Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease.

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